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Scientists find humans age dramatically in two bursts – at 44, then 60

If you have noticed a sudden accumulation of wrinkles, aches and pains or a general sensation of having grown older almost overnight, there may be a scientific explanation. Research suggests that rather than being a slow and steady process, aging occurs in at least two accelerated bursts.

The study, which tracked thousands of different molecules in people aged 25 to 75, detected two major waves of age-related changes at around ages 44 and again at 60. The findings could explain why spikes in certain health issues including musculoskeletal problems and cardiovascular disease occur at certain ages.

“We’re not just changing gradually over time. There are some really dramatic changes,” said Prof Michael Snyder, a geneticist and director of the Center for Genomics and Personalized Medicine at Stanford University and senior author of the study.

“It turns out the mid-40s is a time of dramatic change, as is the early 60s – and that’s true no matter what class of molecules you look at.”

…

ThrowawayPermanente ,

As a 41 year old, goddamnit

Blum0108 ,

Lol literally my thought.

chatokun ,

43: chuckles, I’m in danger.

consumptionone ,

I feel this

Reverendender ,

I just turned 45. Prepare yourself.

villainy ,

Some things scientists should just keep to themselves 😡

MNByChoice ,

This is reassuring, even if not true. The mid-40s slide is a bump, not a new slope.

AA5B ,

Even more hopeful: a sudden change implies a common trigger and maybe something can be done about that trigger (sorry if the article answered it, I didn’t read)

MNByChoice ,

Article focuses on behavior, not on fixing our bodies.

(Humanity has a huge issue blaming the experiencer. A large “you smelt it, you delt it” attitude.)

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

Well that explains why I feel like I’m about 80 now that I’m 47.

Someonelol ,
@Someonelol@lemmy.dbzer0.com avatar

Woah there, save something to degrade in another 13 years.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

It’s okay, my mom’s in her 80s and my dad made it to his 80s and their parents all made it to their 90s, so I have a good 5-15 years to degrade once I turn 60.

dmtalon ,

Interestingly enough, a random couple things happened when I was between 43-44 that lead to me start distance running and run my first full marathon about 4 months before I turned 44.

I was decently fit before, but didn’t run any distance above a maybe 5 miles. I do not remember anything negative happening around that time or shortly after. I was actually increasing my cardio endurance dramatically over the next 5 years or so.

fpslem OP ,

Good on you, I’ve read elsewhere that the better shape you can be in prior to years of decline, the better you handle the natural aging process. I don’t need to do anymore marathons, they’re too hard on my knees, but running/biking and body-weight exercises are part of my attempt to stave off the inevitable.

dmtalon , (edited )

Oh ya… Marathons have come and gone for me :) Initially because they were just expensive but COVID had me WFH full time and the group I ran with was near my work office. So I sort of morphed into running alone and just as maintenance vs. Training for something.

I’m about to hit 53 and try to run between 15-20/miles a week still but I did fall behind on my fitness the end of last year when I had some crazy back spasms after sneezing (of all things) that really set me back. Takes forever to get back. Luckily I do not have any physical issues (knees etc) most if my issues now are not eating healthy enough and general motivation to improve. Sounds like I’ve got about 7 years to get on top of it so I can cruise through that age too :)

fpslem OP ,

back spasms after sneezing (of all things)

This is the true humiliation of getting older. In my 20s I climbed mountains and had plenty of scrapes and mishaps, but I just shook them off and my body just healed up quickly. Now I can tweak my back with a sneeze or be sore for days just by raking leaves. Life comes at you fast.

dmtalon ,

I literally could not get off the floor for around 2h and was panicking quite a bit. Never ever felt so vulnerable before. Do not recommend whatever happened to me :). Good thing is it was just muscle and once healed I was back to 100% It just prevented me from running for over a month.

Bishma , (edited )
@Bishma@discuss.tchncs.de avatar

This article is reminding me of a study a few years back that suggested that (provided you’re otherwise healthy and able bodied) you can get into any level or shape you want (if you put in the work of course) up until 60-something. Then you hit an age wall where about the best you can do is maintain what you’ve got. Suggesting that countering that 40-something aging event by pre-gaming for the 60-something aging is a smart plan.

dmtalon ,

So, I need to get motivated for the next 7 years :)

cmbabul ,

I got like five and a half, but am actively in the process of getting back in shape

dmtalon ,

I need to drop weight I picked up last Christmas when I was injured. Just don’t want to diet :)

AA5B ,

Shor, ive been saying “I need to get into shape” for over a half century, but now i have only a couple years to actually do it? Now that I can’t sleep, ache everywhere, and have bad knees?

Bishma ,
@Bishma@discuss.tchncs.de avatar

I’m not impressed by how my meat mech is deteriorating with time given how much constant maintenance it requires.

AA5B ,

I mean, it’s just like a car though. When you first get one, you can rev it as much as you like, fly over speed bumps and potholes, miss an oil change, and no big deal. However that abuse all comes due at once, when suddenly so many parts are obviously degraded. At that point you may decide to replace your car …. I’m ready to replace my meat mech

DefiantBidet ,

48 here… i used to be able to read the freaking copyright date on those eye charts … once i hit mid 40s i need glasses.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

I just got progressive bifocals. It was nice to be able to read my watch properly again, but not so nice to have to look down whenever I’m going up or down stairs and to have to move my head around all the time to see all the real estate on my monitor since it’s 27".

Duranie ,

I’ve worn contacts for almost 40 years, but got tired of using readers these last several years to be able to, you know, read. After unsuccessfully trying multivocal contacts, I got progressive glasses. My vision? GREAT? The 3 weeks it took to get my brain used to moving my head more and my eyes just right (especially while driving) so that seeing the right part of my prescription wasn’t swinging all over the place and making me nauseous? Fucking hell. That was absolute torture. It’s worth it on the other side at least.

I do kinda miss contacts. I may get a second opinion for my prescription and try again.

Bishma ,
@Bishma@discuss.tchncs.de avatar

In less than 2 years (in my early 40s), my eyes went from better than 20/20 with great close up, to barely 20/20 with astigmatism and I need readers

PalmTreeIsBestTree ,

My eyes started losing strength when I was 15. 10 years later, I still got my near sight vision, but I know that will be gone in about 20 years from now…

Windex007 ,

The idea that anyone would think that our bodies change at a constant rate is so bizarre to me, having gone through puberty myself (not to brag).

solsangraal ,

lol i turned 44 last year and yep. feel like shit all of a sudden

SlapnutsGT ,

Same lol

Cheems ,
@Cheems@lemmy.world avatar

All of a sudden? You mean it gets worse??

dezmd ,
@dezmd@lemmy.world avatar

https://lemmy.world/pictrs/image/79597928-8472-4f9f-8192-118b7be37a67.gif

NineMileTower ,

The research tracked 108 volunteers

Not enough to actually mean anything.

fpslem OP ,

Read further in that paragraph:

Researchers assessed 135,000 different molecules (RNA, proteins and metabolites) and microbes (the bacteria, viruses and fungi living in the guts and on the skin of the participants).

Also, see the previous article in Nature linked in the article. That study looked at fewer proteins, but had over 4,000 participants.

Webster ,

I mean, that makes me even more skeptical. 108 volunteers tracked for that many sparesely populated vectors is 100% going to have hundreds of false positives just due to statistical noise.

RagnarokOnline ,

I nominate NineMileTower for a Pulitzer Prize

NineMileTower ,

I’ll take my Nobel Prize now.

Glemek ,

🚫🔔

SoJB ,

My favorite part of science discourse will always be people self-reporting how little they understand science the math behind statistics by complaining about sample sizes that have nothing wrong with them

NineMileTower ,

Statistics? Statistically speaking they studied 0.00000135% of the population all located in California.

SkyeStarfall ,

Again, proving the point

I don’t have the time or energy to do a full statistic course, but there’s the whole thing of sampling en.wikipedia.org/wiki/Sampling_(statistics)

For a very basic example, say you have 1 million people, 200 000 prefers burgers, and 800 000 prefers pizza, then say out you pick people out randomly from the group of 1 million people

How many do you need to pick out to have a 95% certainty that the ratio falls within 95% of the general distribution in the population? The answer is: 246. 246 is a big enough sample size for a 95% confidence that you are within 95% of the range of the general population distribution in this specific example

There’s a lot more to this, of course, but hopefully this is sufficient to showcase that you do not need large amounts of data to derive conclusive results

Usually in a scientific context you go more the route of calculating the confidence percentage that the data you got is random, also known as null-hypothesis testing, where the confidence percentage is the p-value. So the inverse of that is the confidence that it’s not random

But, again, there’s so much more to statistics than this, this is just the very basics.

NineMileTower ,

I understand sampling, but the sample doesn’t represent the human population. Do the same test to 108 in Okinawa or any other blue zone and watch the results be different.

That’s like only sampling the burger people and then concluding that most people like burgers.

SkyeStarfall ,

Assuming that people are biologically different enough between these two areas that is, or some other localized cause of aging at these years. Which I don’t find particularly likely, but yes, it is an assumption

As always, bigger studies are desirable, but idk if it’s much of a criticism of studies. These are for a scientific audience, after all

Lightor ,

You’re ignoring so many factors though. Lifestyle, diets, different genetic background, etc.
Would those make a difference, I don’t know. But science doesn’t operate by saying “we’ll just ignore all these possible variables and make an assumption.” Having a sample of people all from one US State then applying that to the entire world’s population is not good science.

AYU_YASH_UPA ,

deleted_by_author

    •
    merari42 ,

    There are tons of statistical methods to get reasonable conclusions without an RCT. Some things can not be detected with an RCT, because the experiment is just impossible to run, so sometimes you need methods to do causal identification with observable data. Here you do not even need causal identification methods for observational data. You just need to do some descriptive statistics for a large group of people well to find interesting patterns. Whether this aging pattern in the mid-40s is causal it coincidental is not important at first. The pattern itself is interesting.

    moshankey ,

    Oh, fuck me! I got nothing else.

    dactylotheca ,
    @dactylotheca@suppo.fi avatar

    Fuck, that explains a lot

    MediaBiasFactChecker Bot ,

    The Guardian - News Source Context (Click to view Full Report)Information for The Guardian:
    > MBFC: Left-Center - Credibility: Medium - Factual Reporting: Mixed - United Kingdom
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