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Scientists find humans age dramatically in two bursts – at 44, then 60

If you have noticed a sudden accumulation of wrinkles, aches and pains or a general sensation of having grown older almost overnight, there may be a scientific explanation. Research suggests that rather than being a slow and steady process, aging occurs in at least two accelerated bursts.

The study, which tracked thousands of different molecules in people aged 25 to 75, detected two major waves of age-related changes at around ages 44 and again at 60. The findings could explain why spikes in certain health issues including musculoskeletal problems and cardiovascular disease occur at certain ages.

“We’re not just changing gradually over time. There are some really dramatic changes,” said Prof Michael Snyder, a geneticist and director of the Center for Genomics and Personalized Medicine at Stanford University and senior author of the study.

“It turns out the mid-40s is a time of dramatic change, as is the early 60s – and that’s true no matter what class of molecules you look at.”

MNByChoice ,

This is reassuring, even if not true. The mid-40s slide is a bump, not a new slope.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

Well that explains why I feel like I’m about 80 now that I’m 47.

Someonelol ,
@Someonelol@lemmy.dbzer0.com avatar

Woah there, save something to degrade in another 13 years.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

It’s okay, my mom’s in her 80s and my dad made it to his 80s and their parents all made it to their 90s, so I have a good 5-15 years to degrade once I turn 60.

dmtalon ,

Interestingly enough, a random couple things happened when I was between 43-44 that lead to me start distance running and run my first full marathon about 4 months before I turned 44.

I was decently fit before, but didn’t run any distance above a maybe 5 miles. I do not remember anything negative happening around that time or shortly after. I was actually increasing my cardio endurance dramatically over the next 5 years or so.

fpslem OP ,

Good on you, I’ve read elsewhere that the better shape you can be in prior to years of decline, the better you handle the natural aging process. I don’t need to do anymore marathons, they’re too hard on my knees, but running/biking and body-weight exercises are part of my attempt to stave off the inevitable.

dmtalon , (edited )

Oh ya… Marathons have come and gone for me :) Initially because they were just expensive but COVID had me WFH full time and the group I ran with was near my work office. So I sort of morphed into running alone and just as maintenance vs. Training for something.

I’m about to hit 53 and try to run between 15-20/miles a week still but I did fall behind on my fitness the end of last year when I had some crazy back spasms after sneezing (of all things) that really set me back. Takes forever to get back. Luckily I do not have any physical issues (knees etc) most if my issues now are not eating healthy enough and general motivation to improve. Sounds like I’ve got about 7 years to get on top of it so I can cruise through that age too :)

fpslem OP ,

back spasms after sneezing (of all things)

This is the true humiliation of getting older. In my 20s I climbed mountains and had plenty of scrapes and mishaps, but I just shook them off and my body just healed up quickly. Now I can tweak my back with a sneeze or be sore for days just by raking leaves. Life comes at you fast.

dmtalon ,

I literally could not get off the floor for around 2h and was panicking quite a bit. Never ever felt so vulnerable before. Do not recommend whatever happened to me :). Good thing is it was just muscle and once healed I was back to 100% It just prevented me from running for over a month.

DefiantBidet ,

48 here… i used to be able to read the freaking copyright date on those eye charts … once i hit mid 40s i need glasses.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

I just got progressive bifocals. It was nice to be able to read my watch properly again, but not so nice to have to look down whenever I’m going up or down stairs and to have to move my head around all the time to see all the real estate on my monitor since it’s 27".

Bishma ,
@Bishma@discuss.tchncs.de avatar

In less than 2 years (in my early 40s), my eyes went from better than 20/20 with great close up, to barely 20/20 with astigmatism and I need readers

Windex007 ,

The idea that anyone would think that our bodies change at a constant rate is so bizarre to me, having gone through puberty myself (not to brag).

Jezebelley ,
@Jezebelley@fedia.io avatar

I only have a couple years left before the old officially sets in it that's the case. Save me...

solsangraal ,

lol i turned 44 last year and yep. feel like shit all of a sudden

NineMileTower ,

The research tracked 108 volunteers

Not enough to actually mean anything.

fpslem OP ,

Read further in that paragraph:

Researchers assessed 135,000 different molecules (RNA, proteins and metabolites) and microbes (the bacteria, viruses and fungi living in the guts and on the skin of the participants).

Also, see the previous article in Nature linked in the article. That study looked at fewer proteins, but had over 4,000 participants.

Webster ,

I mean, that makes me even more skeptical. 108 volunteers tracked for that many sparesely populated vectors is 100% going to have hundreds of false positives just due to statistical noise.

RagnarokOnline ,

I nominate NineMileTower for a Pulitzer Prize

AYU_YASH_UPA ,

Unrelated but I need help!!!

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I’m not able to post images anywhere on lemmy and always get an error.Why???

AYU_YASH_UPA ,

If this is not a randomised control trial,it is a baseless conclusion!!!

merari42 ,

There are tons of statistical methods to get reasonable conclusions without an RCT. Some things can not be detected with an RCT, because the experiment is just impossible to run, so sometimes you need methods to do causal identification with observable data. Here you do not even need causal identification methods for observational data. You just need to do some descriptive statistics for a large group of people well to find interesting patterns. Whether this aging pattern in the mid-40s is causal it coincidental is not important at first. The pattern itself is interesting.

moshankey ,

Oh, fuck me! I got nothing else.

dactylotheca ,
@dactylotheca@suppo.fi avatar

Fuck, that explains a lot

MediaBiasFactChecker Bot ,

The Guardian - News Source Context (Click to view Full Report)Information for The Guardian:
> MBFC: Left-Center - Credibility: Medium - Factual Reporting: Mixed - United Kingdom
> Wikipedia about this source

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