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FDA approves new version of diabetes drug Mounjaro for weight loss

A new version of the popular diabetes treatment Mounjaro can be sold as a weight-loss drug, U.S. regulators announced Wednesday.

The U.S. Food and Drug Administration approved Eli Lilly’s drug, named Zepbound. The drug, also known as tirzepatide, helped dieters lose as much as 40 to 60 pounds in testing.

generic ,
@generic@iusearchlinux.fyi avatar

Manjaro? I use that on my computer!

Oh, you said Mounjaro? Never mind.

sebinspace ,

“I use Arch btw”

Zozano ,

Manjaro users don’t have the superiority complex required to be this prude.

ObviouslyNotBanana ,
@ObviouslyNotBanana@lemmy.world avatar

It’s because they have no idea how their system actually works

This comment was made by the Real Arch Gang

DarkenLM ,

I personally know a handful of people that also don't know how the fuck Arch works but still use it.

ObviouslyNotBanana ,
@ObviouslyNotBanana@lemmy.world avatar

Yeah I was just kidding. I don’t use it myself. Those people are everywhere though, I can confirm.

DarkenLM ,

I figured.

Arch is great for people with a very extensive knowledge about the entire system, or for masochists. One wrong command and the whole thing catches on fire.

Respect for those who know how to use it and are not assholes about it, though.

turbowafflz ,

In my experience once you get it set up arch isn’t that bad. I can only really remember one time it really broke and that was when my laptop ran out of battery during a kernel upgrade (I know I should have had it configured to keep multiple kernels but for some reason I didn’t). I’m using opensuse a lot more recently though and it definitely is easier, just not by like an insane amount

Zozano ,

Getting Arch set up from scratch is a great learning experience. I recommend everyone to at least try to install it once properly, you’ll definitely come away with a better understanding of the system.

ObviouslyNotBanana ,
@ObviouslyNotBanana@lemmy.world avatar

Definitely. I’ve tried it, it wasn’t my thing. I get it, but it’s not for me.

Zozano ,

“I use Manjaro BTW”

(“I use Manjaro, please don’t bully me or ask me to use the terminal. Also, why hasn’t Manjaro renewed their SSL certificate?”)

flicker ,

I'm on Wegovy and it's a miracle, frankly.

Between the ADHD medication wreaking havoc with my hunger signals and the non-diabetic hypoglycemia causing me to go from "not hungry" to "dying of a sugar crash," the Wegovy gave me actual satiety for the first time in my life, and evened out the crashes.

I'm a big fan of more options along these lines, for whoever they might save.

SeaJ ,

Unfortunately people gain the weight back once they stop taking the drug if there is no lifestyle change which there often is not. A guy I know owned a good chunk of Sequence which essentially fast tracked access to Wegovy through telehealth and working with insurance companies. He was pushing to partner with a company that could provide that lifestyle change info so that people could keep off the weight when they stop using it. Weight Watchers bought them so hopefully they can help provide that lifestyle change.

So far the side effects of Wegovy are fairly standard but it has only been around for 10 years and widely studied for an even shorter period since it has only been on the market for a couple years.

flicker ,

I know that it's a lifelong drug. I don't care. I'll take it. Especially because of the evened out crashes! Not having a sugar high or a sugar low is so wonderful for someone who has spent 37 years enslaved to snacks.

Revonult ,

Okay so everyone is different but I just found out my non-diabetic hypoglycemia was almost entirly caused by my stimulant ADHD medication. I had been taking it for 12+ years and always thought the hypoglycemia was just how my body was, but it has been night and day. It was very hard to move away the the meds but but I know EXACTLY what you mean by the sudden “dying of sugar crash”. Obviously the ADHD still needs treat but I will be moving to a non-stimulant for treatment.

flicker ,

I'm upvoting you and I'm going to share your story with others but unfortunately I know this isn't the case with me, as I was adult diagnosis ADHD and dealt with the hypoglycemia since elementary school. I only tried stimulant medication for the first time two years ago.

But I wonder if any studies have been done about frequency of ADHD and hypoglycemia comorbidities! Seems promising!

reluctantpornaccount ,

The track record for weight loss drugs is not good. Even “approved” ones. We had a lot of teenagers on amphetamines to make them lose weight.

The podcast Maintenance Phase has at least one episode on them and their history.

Salamendacious OP ,
@Salamendacious@lemmy.world avatar

I’m personally a big fan of consuming fewer calories.

piecat ,

Great point, how do you think weight loss drugs work?

They make you less hungry or curb your cravings… Making you eat less.

Salamendacious OP ,
@Salamendacious@lemmy.world avatar

Or you can just eat less

Modern_medicine_isnt ,

But can you? When your body is constantly screamming eat more. Those who can assume everyone can, but not everyone can.

Salamendacious OP ,
@Salamendacious@lemmy.world avatar

I believe yes. I think it’s hard but I think you can. Weight loss drugs, liposuction, stomach stapling, etc none of those methods helps someone learn to control their cravings or redirect their cravings. We live in a world of excess. There’s food everywhere you turn. It’s like a recovering alcoholic. He or she needs to learn to live in a world where alcohol is omnipresent but they have chosen to not indulge their inner cravings. Someone can be craving horrible food and choose to eat salads without creamy dressing. You can choose to not drink sugary drinks. You can crave ice cream but choose to eat raw carrots instead. Is it as fun? No. But alcoholics walk by bars and liquor stores every single day and they choose to not indulge their cravings. It isn’t as fun but they do it regardless.

TheActualDevil ,

To use your alcoholic analogy. Imagine you were a terrible alcoholic and you decide to get better. Great! But you can’t STOP drinking. Not completely. You have to stop drinking too much while also NEEDING to have 2-3 single drinks a day to survive. So every day. Every. Single. Day. Multiple times a day you have to face that temptation. Your brain and body are craving you down a fifth of vodka when you wake up, but you’re only supposed to drink a watered down Bloody Mary instead. You have to taste that vodka and get a tiny bit of that dopamine hit from it, but you just have to stop. Your kitchen is full of liquor bottles, but you have to just wait until lunch to have your next drink with that craving eating away at you.

And then you hit the breakroom at lunch to sip on your small shot of whiskey you brought from home, but the breakroom is a cocktail bar and everyone around you is downing a couple pints of lager or a Long Island Ice Tea. There’s an open bar right there! Plenty of drinks easily available and your mind is begging you to just go get some. But you’re not abstaining completely. You just have to sit there and sip on your tiny bit of alcohol and that’ll just be enough.

For your nightly drink, you always take it at home. You can’t go to a restaurant with anyone, or even by yourself. You can’t order in. The smallest drinks they serve is a full pint. And still, while you down that Manhattan as quickly as you can every night so as not to think about it too much, you have to go to your kitchen to prepare it with the shelves full of liquor. And just have that one drink. Everyone else gets to have a few drinks a day and move on with their life, but for you every meal is a fight to not go off the deep end while dipping your toes just a little into the pool.

And then tomorrow you have to wake up and do it again.

And every day for the rest of your life.

And that’s just me trying to appeal to your empathy, assuming you have any. There’s science that shows that the dopamine (or maybe serotonin, I always get them confused) that food addicts get is just as addictive as a hard drug habit. It’s literally the same thing. That’s why drugs feel good. It’s not just the altered state that’s addictive. The chemicals your brain release when it gets these things make you crave more. Some people’s brains light up from eating some foods. It’s the same thing as a drug habit, but you can’t quit. Ever. There’s science to back up how wrong you are. You just don’t have to deal with it and you can’t imagine how anyone could have different experiences than you.

Salamendacious OP ,
@Salamendacious@lemmy.world avatar

My favorite part of this is your assumption that I have no personal experience in any of this. I know that it’s hard. I also know it’s possible to stop drinking and stop eating to excess. These are not analogies for me.

Senshi ,

That’s like telling depressed people “just don’t be so down”. It shows a lack of empathy as well as medical ignorance.

Salamendacious OP ,
@Salamendacious@lemmy.world avatar

No it isn’t. You can’t choose to not be depressed but you can choose to eat less and accomplish it through willpower.

reverendsteveii ,

Where does willpower come from?

Salamendacious OP ,
@Salamendacious@lemmy.world avatar

Merriam-Webster’s definition of “willpower”: www.merriam-webster.com/dictionary/willpower

GissaMittJobb ,

‘lmao like how are people homeless, just get a house’

Salamendacious OP ,
@Salamendacious@lemmy.world avatar

People can have self control. It’s possible through nothing more than willpower to choose to eat less and just do it. Just like how there are people who choose to stop drinking alcohol. They chose to be sober and then they worked at being sober. Some people get help with support groups but there are a lot of sober people who just choose to stop drinking. People can infact choose to eat less. I’m not saying it’s hard but it is possible. No one can choose to have a house through willpower alone.

You can downvote me all you want. It doesn’t bother me in the slightest. Because I think it’s so incredibly weird how every little imperfection now needs the pharmaceutical industry to sell you a pill to fix it. Medicine is one thing. Antipsychotics, schizophrenia, ADHD medications, etc. there are plenty of things that require medication. But weight loss? Come on. Unless you have some diagnosed underlying condition, which I imagine is rather rare, then you don’t need a pill to lose weight. You are capable of doing on your own.

GissaMittJobb ,

Yeah, just like homeless people can just get a house, overweight people can just eat less. Simple shit with no more nuance whatsoever. No need for any deeper investigation of these complex topics. Let’s keep minimizing both of these groups without any form of empathy like the piles of shit we make ourselves out to be.

reluctantpornaccount ,

Not all of them. Some of these drugs can affect nutrient uptake, others are amphetamines to make your resting energy use rise, as a stimulant. I’m sure there are other mechanisms to mess with as well.

piecat ,

Amphetamines basically make you not hungry. That is the primary mechanism anyway.

books ,

Eh these people are either gonna be taking bp/cholesterol/diabetes medication or this. Seems like it has the potential to be a wash?

SeaJ ,

The results for this and Wegovy are pretty promising. That said, the long term effects are unknown since they are so new. But the long term effects of having a BMI over 30 are pretty terrible and well known. These are nothing like amphetamines.

ChexMax ,

The results are that they were only tested on perfectly healthy people which is not indicative of their success in the general population, and the results were also that most people gained the weight back immediately upon stopping the drug.

The side effects were not too bad for people getting the drug for free, but at 1k a month, those side effects cause much higher drop out rates as well.

Still way more promising than anything else available, but not that promising overall.

SuiXi3D ,
@SuiXi3D@kbin.social avatar

Ha! A grand a month. Fat chance.

LordOfTheChia , (edited )

But it works. After paying for the med, you can no longer afford food for the month.

SuiXi3D ,
@SuiXi3D@kbin.social avatar

Big brain.

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