Hot

cross-posted from: lemmy.world/post/1750098...

β-Arrestin recruitment is a ubiquitous mechanism of negative regulation of GPCR signaling, which has been demonstrated for almost all GPCRs. Recently, β-arrestins have been shown to act as signaling scaffolds for numerous pathways, such as Akt, c-Src, and ERK 1/2, in a G protein-independent manner. G protein and β-arrestin...

I’ve been thinking about the arguments that are increasingly common when dealing with tech: “it’s too complicated” and “I just want something that works”....

Hello community, looking for your wisdom, I need a tool / addon / script / whatever free that works for windows to download videos from i.e. netflix or prime video. ty!

Title.

Hey everyone! I’m looking for some good documentaries on the history of computer science and Programming in general!...

Just thinking about all the… Shall we say “under used” pickup trucks in my neck of the woods. Bought to look like the owner moves shit - when in reality it just signals to me they have the money to make others do it for them.

I know electricity will take the shortest/easiest path to ground, and that path for a wire wrapped around a bigger wire/cable should be shorting through the bigger wire....

I want to run two instances of Stremio in my Nvidia Shield TV which is running Shield Experience 8.2.3 but I don’t know if it is possible to create a duplicate of it....

I originally chose to make my account on lemmy.world since all the content seemed to come from there. But I’ve since learned that I can fill my feed with stuff from any instance so it feels like it doesn’t actually matter if I’m on lemmy.world or not. At the same time, Lemmy.world seems to be frequently under attack so...

I use coolercontrol to set fan curves, but the application needs to be open for it to work. If I run GPU pass through there is no X server running, so the app can’t stay open while running the VM and I have no control over fan curves....

If you Google something and the results you need is on a reddit page but you’re unable to view for any reason, such as the user deleting the post or the sub going dark, there is a work around to get the info you need. Copy the link from Google and In your web browsers search bar/ URL bar type Cache: followed by the URL you...

I was watching the tv series on Apple TV and got hooked. The pace was a little slow though and some parts of the plot seemed over worked and drawn out. Nevertheless, the premise for the show was so intriguing to me that when the first season ended on a cliff hanger, I opted to jump into the books instead....

Hello All,...

Anyone know why sh.reddit.com exists? Is it something they plan to use in future? ATM, it just looks justlike reddit.com with a few small style differences.

I just wonder what do you guys think about security of instander. I honestly don’t want to lose my dms. Also, have you heard about honista? It smells like scam shit. Cheers

Anyone else?

On Twitter I mostly followed people I knew in real life, comedians, some novelty and parody accounts. I joined Mastadon and I really don’t see anything interesting to me looking at trending posts and what not. It seems very grown up and dry. I miss a little of the “Wild West” aspect of twitter from early 2010’s with...

And I absolutely loved it. It is honestly one of my new favorite books. I am going to tag basically this whole post as spoilers because the thing that truly makes this book amazing does not start until almost 100 pages in....

[reposted from reddit]...

I’ve been fostering a family member for a month or so, and it all came to a head today. My wife and I tried, but the behavior was just too much for us to feel safe with our existing children. I hate that we’re giving up and I hate the circumstances that caused this, but it is what it is. If you’re in the same place please...

Hi all...

Theyre coming to my area later this year apparently. I was wondering if anyone had an opinion on the quality of service?...

I read The 7 1/2 Deaths of Evelyn Hardcastle, and take enjoyed it. Read another book, then started reading Devil and the Dark Water by the same author. I got about 25% through and just decided to drop it for something else. I’m not an avid reader so i never know if I should stay committed or not.

I know we pretty much all hated spez for all the shit he pulled, but a few weeks ago the tone towards reddit itself around here was more neutral. People liked it here on Lemmy a lot better, but people weren’t hating on the old place so much....