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cheese_greater , (edited ) to news in Oral ketamine tablets effective for treating depression, new study finds

They should make a one high-dose 3-4th plateau DXM pill available also

Sell them in a 3-pack 4 pack so you can have one wild 4th plateau or 2+ smaller trips lol

b3an ,
@b3an@lemmy.world avatar

I wish they’d be used to help people with agonizing depression and help them to feel like a person again. Not so people can just abuse them to get high.

cheese_greater ,

You can’t always seperate all these things out. I do it rarely because its sort of a severe experience (physically, def gonna throw up at least once and the pee-inhibition is terrible, plus walking and eyes are weird) but I need a reset every now and again when I get in a rut. It can also be pleasently disorienting in a way that makes you really question some of the insignificant sideshows we get distracted by.

It realy shouldn’t matter altho I agree that people shouldn’t use it as a party drug. It should be more like one of those glass windows with a defribillator and you smash it when you need it but its seen as a pain in the ass to access for frivolous means.

But everyone should have easy access and not in ways that maximize side effects or difficulty. Its the biggest shame in the world that so many lives and time were lost because of dumb drug war propaganda that arbitrarily restricts people in such a silly way.

Rediphile ,

I think allowing people who abuse them to, well, abuse them is an acceptable byproduct of also helping meaningfully treated various other peoples depression.

It’s not one or the other.

SturgiesYrFase ,
@SturgiesYrFase@lemmy.ml avatar

Eh, ket destroyed my friend’s life for almost a decade. He was shooting it, hooking to afford gear and sucking his landlord’s dick to have somewhere to stay. Broke into his mum’s house and stole anything of value. Did time, cleaned up, and is now sober. I think if we’re going to open up these drugs for free use, we need to build effective support systems so that recreational use doesn’t turn into abuse to the extent that its destroying the lives of the abuser and those of everyone around them.

Rediphile ,

Okay, but didn’t that happen in an environment where ket was not legally available for people who may be able to benefit from it? Like…that shit already happens. And yeah it sucks.

Do you not feel he would have benefited from it being legal when he attempted to seek treatment? Might he have had less motivation to steal and suck his landlords dick if the illegal market didn’t make the drugs so cost prohibitive?

Akuma , to news in Oral ketamine tablets effective for treating depression, new study finds
@Akuma@pawb.social avatar

The article is behind a paywall, so here is the link to the study: www.nature.com/articles/s41591-024-03063-x

Sound promising at a first glance.

Fondots , to news in Why the FDA will have a hard time properly regulating cannabis

First of all, I’m not at all against medical (or recreational for that matter) marijuana. It helps people, and those people should have access to medications that help them, and I’d rather have the current system than no access to medical marijuana at all. I feel like I need to start off with this because otherwise I feel like parts of this comment may come off as anti-marijuana, and that’s not my intention at all.

But it’s always been kind of wild to me how the programs we have are handling medical marijuana, I’m pretty sure if a doctor tried to handle any other medication like we usually handle medical marijuana, he’d lose his license.

Marijuana isn’t one drug, it’s several, THC, CBD, Terpenes, various other cannabinoids and other active ingredients, all with different interactions with your body and with each other that can produce a variety of effects on their own or in combination with the others.

And often you’re given little to no medical guidance on which ones will actually help with which issues, how much or how often you should take them, and in what way.

It’s kind of like being given a bucket of assorted pills that may or may not help your condition and being told to mix and match them and try taking them in various ways until you feel better.

And don’t even get me started on smoking it. Yes, it can be an effective delivery method, and you can go back and forth on how marijuana smoke is more or less harmful in various ways than tobacco, but at the end of the day putting smoke in your lungs is bad for you, and I don’t think there’s a doctor in the world who would disagree with that. If nicotine was some sort of wonder drug that could help with various conditions and you could get a prescription for it, I guarantee you it wouldn’t come in the form of tobacco, you’d get pills, patches, maybe some kind of inhaler, vape or nebulizer, injections, suppositories, etc. some sort of purified product with a known dosage.

It’s practically impossible to really do medical grade QA on a plant, there’s going to be variation from one plant to another, or even from different parts of the same plant depending on weather, light, water, fertilizer, and other variables in the growing conditions, not to mention just the genetic variations in the plants, and knowing exactly how much of which active ingredients are in the product is kind of key to being able to dial in what is an effective dose.

Yes, a lot of that has to do with all of the shitty laws and regulations we have around marijuana and our broken medical system in general, I’m not going to go into that too much because this comment is already going to be long enough that a lot of people won’t read it, but I’ll leave it it’s hard to study marijuana to figure what works and how, and it’s hard to build up the kind of industry needed to make actual pure and consistent medical grade marijuana products.

Now of course, if we handled medical marijuana the way it probably should be for the best results, it would probably turn out to be a hugely expensive undertaking under our current healthcare system. There’d probably be a lot of doctor-patient interaction to help you dial in your dosages, with more guidance on how and when to take it, we’d probably be getting into territory where you’d need some sort of a compounding pharmacist who could provide you with a custom blend of the right active ingredients in precise ratios in the delivery method that’s most effective for your condition and needs, there’d be a huge pharmaceutical industry (and probably all of the corporate greed that goes with it) that would need to be built to provide these medications, etc.

And unless we have some major overhaul to our healthcare system, that would all probably price a lot of patients out of being able to afford these treatments.

And yes, the current system works well enough for a lot of people, but it’s possible that it could work even better for them and for even more people if we treated marijuana more like other medications.

I don’t exactly have a grand plan on how to fix things. I don’t want to make marijuana more expensive or inaccessible for the people who need it. I don’t want to feed into the pockets of big pharma. But I do want to make sure that our treatments are as effective as possible, that we’re treating marijuana seriously as a medication and that people view it as such, and that we’re not just settling for our treatment options being “good enough” when we can do even better. We didn’t stop at willow bark, we built on it to develop modern aspirin and other NSAIDs, and someday we will probably do the same for marijuana, there will probably come a day when almost no one will turn to plant-derived marijuana products for medical reasons because we will have long since isolated, synthesized, and developed entirely new classes of drugs based on what we learn from studying marijuana that do the same things more effectively, more safely, and with even less side-effects.

skulblaka ,
@skulblaka@startrek.website avatar

If we had an appropriate scheduling for it so that it could be properly researched and manufactured we could just treat it like every other plant-based medicine we have (of which there are VERY many) - isolate and extract the compounds you’re interested in and recombine them in a pill or gel or aerosol form. Making supplements or tinctures or whatever, from cannabis, wouldn’t be any more difficult than creating aspirin from willow. The only reason it’s difficult is because it’s so highly scheduled that nobody is allowed to work with it.

Dkarma ,

Op is a moron. Any decent bud tender can tell u exactly what that bud will do for you and if you get it wrong? Oh no nothing really catastrophic happens except u may get paranoid.

Ok now try that with any pill…oh ur dead? Yeah…

FlyingSquid , to news in Why the FDA will have a hard time properly regulating cannabis
@FlyingSquid@lemmy.world avatar

It’s a plant. Plants should be legal to grow. Maybe sometimes you will have to take steps if you want to grow it and it’s an invasive plant, but it’s still a fucking plant.

I use cannabis medicinally, and it’s true that I would prefer to vaporize it (I don’t smoke) when I use it than take some sort of pill. Because it gives me very fast pain relief. I’m sure if inhaling ibuprofen worked much faster than taking a pill, people would do that too.

bizzle ,
@bizzle@lemmy.world avatar

I also smoke it (I don’t vaporize) medicinally for my leg and I can go from “literally can’t stand up” to “pretty much fine” in like 4 tokes, it’s amazing 👍

But one of the side effects I’ve been experiencing lately is that I’m always having a great time, which some people really seem to have a problem with 🤔 I can’t figure it out.

I can’t help but say commodity cannabis ruined weed though. Dudes should be growing it in their back yards and sharing it freely with their dawgs, not paying $300 an ounce at a dispensary that feels like the DMV. The cannabis industry MUST be deregulated.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

Most (every?) state where it’s legal allow you to grow your own plants.

bizzle ,
@bizzle@lemmy.world avatar

We can only grow in Illinois with a valid medical card, otherwise it’s a $200 ticket. The police union fought back when they wanted to let everyone grow.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

I would hope that would also be changed with federal legalization. Getting the FDA involved shouldn’t be a roadblock to that. The FDA doesn’t get involved when you grow your own vegetables.

bizzle ,
@bizzle@lemmy.world avatar

Fingers crossed

verdantbanana ,
@verdantbanana@lemmy.world avatar

the point of dispensaries is to not have a product grown in a backyard that is lab tested

does anyone here not remember the before times?

also would you buy your lettuce from Earl on the corner or from the store?

what is the quality of the soil in these backyards

now.tufts.edu/…/backyard-chickens-and-risk-lead-e…

bizzle ,
@bizzle@lemmy.world avatar

I still get mine from Earl 😂

In seriousness backyard product does have risks, but so does dispensary stuff. A lot of these labs just rubber stamp stuff. I’ve read exposés on the cannabis industry that read like Upton Sinclair.

eyeon ,

The commerce should be regulated imo- there’s a lot of bad things people will do for profit when not properly regulated.

That doesn’t prevent you from growing your own or consuming your buds bud, that’s just personal use and does not need to abide by the same regulations

TheRealKuni ,

$300 an ounce at a dispensary

Damn. Living in Michigan is pretty great on this front. Weed is dirt cheap at dispensaries here.

bizzle ,
@bizzle@lemmy.world avatar

Our supply is kept artificially low by overregulation. You need something like a million dollars in liquid money to get the permits to grow commercially and they only give out a handful of licenses per year, ensuring that the rich get richer and everyone else gets fleeced. Still better than Iowa where “any amount” leads to jail time.

TheRealKuni ,

That blows. I’ve heard some people complain similarly here, but the bar seems at least somewhat lower.

I’m just thrilled I can go to a store with posted hours, rather than calling a guy who says to come to his house and then isn’t there, tells you to wait for him, and two hours later finally shows up to tell you he doesn’t have anything for you.

(Not that this was my normal experience, but it happened enough to make me despise most dealers.)

Today ,

Is Michigan one of the states that they can’t ship hemp to? I didn’t think it was on the list. Eight horses hemp, flow gardens, hoku seed company… There’s a ton of legal weed out there that’s very reasonably priced.

bizzle ,
@bizzle@lemmy.world avatar

I’m in Illinois so I’m not super familiar, but although hemp is better than nothing it’s definitely not the same

Today ,

There’s hemp online with 20% thc or higher. It sells out quickly, but if you get on the email lists you’ll know when its dropping.

Bartsbigbugbag ,

Here it’s like $100-140/oz, but quality fell massively after legalization. Like, really, genuinely, the worst chronic from before legalization is better than all but the best after.

Hathaway ,

deleted_by_author

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  • FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    Do you know how many poppies it takes to make significant amounts of opium or heroin? We’re talking micrograms per gram of plant.

    Why shouldn’t growing it be legal? It would be pretty easy to find out if you were processing the stuff into something illegal.

    verdantbanana , to news in Why the FDA will have a hard time properly regulating cannabis
    @verdantbanana@lemmy.world avatar

    the whole point of the FDA taking over cannabis is the same as nicotine vaping

    shut down the industry with over regulation that sounds positive on the surface

    treefrog ,

    Seems like if they wanted to shut it down, rescheduling it first would be an unnecessary step since it’s currently schedule one.

    It will be a messy transition, as the article points out. But I doubt the point is to shut it down. Especially considering the political climate around cannabis and the messaging from the White House.

    verdantbanana ,
    @verdantbanana@lemmy.world avatar

    but rescheduling allows them to add regulations just like when this happened to ejuices

    gedaliyah ,
    @gedaliyah@lemmy.world avatar

    Unlikely. The public and political agendas are just the opposite for the two substances: most people support the expansion of cannabis products and oppose the expansion of nicotine products.

    verdantbanana ,
    @verdantbanana@lemmy.world avatar

    safe effective nicotine consumption were generally supported by the public too and was being ingrained in the culture in movies and tv

    now it is combustible cigarettes with alcohol being heavily promoted again as well in television and film

    if the US does not stop voting in senile past retirement age religious right leaning presidents who view any alteration in the citizen’s conscience it might not ever change or get better

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    safe effective nicotine consumption

    What evidence do you have that there is such a thing?

    verdantbanana ,
    @verdantbanana@lemmy.world avatar

    the synthetic nicotine being produce is done with green chemistry meaning no heavy metals used in synthesis

    with the nicotine being lab made no ground pollutants such as lead and other heavy metals are present just like fake vanilla extract which most seasoning coming from India with polluted soil

    also less soil less environmental impact

    the ingredients have gotten safer over time as well also leading to changes in other industries

    hugely better product both health and environmental and all around

    not to mention not have the ill effects of second hand smoke

    my own lung capacity was around 80% and dropping during the years was consuming combustible nicotine and cannabis products but now is above 90% had my lungs checked by a doctor

    lightyears healthier

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    None of that has to do with your claim, and it is also more claims instead of evidence.

    Where’s your evidence that there is a safe level of nicotine consumption?

    treefrog , (edited )

    Nevermind this, see my reply to squid below. I was operating under the wrong view that nicotine by itself is not cancer causing.

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    Safer is not safe.

    I agree, it’s safer. But how can we know it’s safe below a certain amount for lifelong vapers when there hasn’t been enough time to do a long-term study?

    Wouldn’t (and I say this as a long-term cannabis vaporizer myself) putting anything into the lungs on a regular basis other than air be inherently unsafe long-term?

    treefrog ,

    Nothing is 100% safe. Which is why harm reduction is an important part of the conversation when discussing drug addiction.

    Water is safer than tea. Tea safer than coffee. All three can in theory kill you if consumed in large enough quantities.

    Anyway, I figured I would dig around more on vaping instead of just glancing at the top search result.

    And, I take what I said back. Nicotine by itself causes cancer. Tobacco just makes it more likely.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC9222281/

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    I don’t disagree with you on the “safer” thing at all, but OP said that it was “safe.”

    But this has become moot anyway based on your research.

    treefrog ,

    Yeah, my bad for glancing at the top search result before I made my long-winded post above lol.

    Hope you’re well, Mr. Squid.

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    No better than I have been in over a year, but we’re working on it. Thanks.

    treefrog ,

    Sorry to hear that. My mental health is finally on the mend. Giving myself permission to be myself for the first time in my life, really.

    Hope things get better for you soon :)

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    That’s great! Good luck to you!

    treefrog ,

    Thanks!

    treefrog ,

    As flying squid helped me see, safer doesn’t mean safe.

    Nicotine alone can cause cancer and while vaping is ‘safer’ than tobacco, in that it’s less carcinogenic, it is still a carcinogen. And because of the ROA, vaping is actually more addictive than cigarettes.

    www.ncbi.nlm.nih.gov/pmc/articles/PMC9222281/

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    If that was their goal with vaping, it’s been a spectacular failure. So I say they should go for it.

    verdantbanana ,
    @verdantbanana@lemmy.world avatar

    no it has not been a failure

    the government was able to shut down most of the vape companies

    some of them were very up to code being made in clean rooms good enough to make pharmaceuticals

    now we have big tobacco vapes mixed in with shoddy products

    have you talked to industry leaders such as business owners of some of these vape companies?

    nicotine and cannabis industry is in shambles due to bad policies and laws

    no wonder look at the right leaning conservatives that keep getting voted in with the latest one having a prosecutor as a vice

    cannabis being rescheduled and not legalized is a trojan horse designed to make the people feel complacent and happy with only extreme regulation and the disappearance of sustainable, innovative products being the end result

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    I see people vaping all over the place. If their goal was to shut down the industry, that sounds like a failure to me.

    This also sounds like a failure of their goal:

    Reported sales of cartridge products increased from $2.133 billion in 2020 to $2.496 billion in 2021; sales of disposable, non-refillable e-cigarette products increased from $261.9 million in 2020 to $267.1 million in 2021.

    ftc.gov/…/ftc-issues-third-report-e-cigarette-adv…

    Generally, profits of an industry the government is shutting down don’t go up.

    homicidalrobot ,

    Sure the industry is gaining money, but you’re ignoring specific company shutdowns and restrictions that shaped the industry out of the hands of certain players. There have been a lot of regulatory fingers in the pie, particularly above state level, that weren’t aimed at making the populace safer but instead at making those companies unable to produce or sell their most popular products. There’s also a lot of legal language bites like “e-cigarette” and “open container” that are seeing non-uniform interpretation in legal states, across vape legislature and cannabis legislature alike.

    Draconic legislature isn’t quite turning the country into a hellscape for consumers, sure. But it’s clearly a possible side effect that isn’t being considered, especially as states are beginning to take it upon themselves to start outlawing studied hemp-derived cannabinoids (like delta8/10 or THC-P or THC-A) that are provided for under the 2018 farm bill.

    Tl;Dr while the industry is growing, it’s clear it has enemies with legal power and that’s the crux of the complaint.

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    Okay, but this is what OP said:

    the whole point of the FDA taking over cannabis is the same as nicotine vaping

    shut down the industry with over regulation that sounds positive on the surface

    The vaping industry has not been shut down, it’s growing, as I demonstrated. So, again, if that was their goal, it was a spectacular failure.

    homicidalrobot ,

    Cool restatement. Did you actually read what I posted instead of snipping that post though? I acknowledge it isn’t working, but you can CLEARLY see intent of decisions there skewed toward market control of a new industry, especially based on the similarities (Product control focused on appeal, not risk) of legislature brought forward compared to previous concerns

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    I wasn’t quoting you, I was quoting what OP said and why I responded to it the way I did. OP claimed the goal was to shut the vaping industry down. I showed why that wasn’t true. It’s not my fault if you responded to me with some unrelated point.

    homicidalrobot ,

    You don’t understand my point and you wanted to dunk on someone, it’s cool. Keep posting every 2 minutes without actually reading, I’m sure the karma is good for something dude

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    Since your point was unrelated to mine, the only thing I don’t understand is why you replied to me about it.

    Hugh_Jeggs , to news in Melinda French Gates, going solo, aims to influence reproductive rights in the U.S.

    French Gates sounds like an outdoor version of French doors

    jaybone ,

    But French doors can already be an outdoor version of French doors.

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    But a little silly to put between fence posts.

    RagingRobot ,

    I thought it was when you used your tongue on the gate

    jeena , to news in Melinda French Gates, going solo, aims to influence reproductive rights in the U.S.
    @jeena@piefed.jeena.net avatar

    Bilionairs should not exist.

    neidu2 , (edited )

    deleted_by_author

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  • Owljfien ,

    I think it was implied that the currency was US Dollars

    nucleative ,

    Of all the billionaires who do exist Bill and Melinda would probably agree with you. Bill has been pretty clear that he always played the game to win but he’s also stated he intends to give it all away and he’s openly recruiting other billionaires to give it all away as well.

    I suppose evil billionaires could give it away to make the world a worse plCe, say by developing something like sharks with lasers on their heads, But again in these guys case they’re giving it away to help eliminate malaria around the world.

    If all billionaires were like Bill and the Melinda I suppose the world would be a significantly better place.

    FlyingSquid ,
    @FlyingSquid@lemmy.world avatar

    Bill Gates puts ridiculous conditions on the money he gives, usually so that they benefit him in some way.

    If you want to tout a billionaire as a person to laud, then look to Jeff Bezos’ ex-wife, MacKenzie Scott, who really is giving it away and with no strings attached.

    newthrowaway20 ,

    If all billionaires were like Bill and the Melinda I suppose the world would be a significantly better place.

    If no billionaires existed, the world would be even better than that.

    Every time Bill or Melinda Gates are mentioned, there’s always someone waiting to suck their dick in the comments.

    bolexforsoup ,

    Agee with your comment. Don’t love the homophobic/gendered “suck their dick” aspect.

    bolexforsoup ,

    Bill Gates ruined lives as he cheated, lied, and stole his way to the top. I actually do respect a lot of the work he has done in his later years but let’s not forget the monster he was and how his terrible treatment of others created that wealth. They weren’t called the Pirates of Silicon Valley for nothing.

    Ultimately that money shouldn’t be in his hands anyway. It should be in the hands of the government, which makes it accountable to us via the representatives we vote in. We as society should dictate where these things go, not a few individuals controlling a disproportionate amount of wealth they did not even earn. He could wake up tomorrow and say “you know what? Trump is right and I think vaccines are bullshit” and there’s nothing we can do about it. Billions of dollars would potentially flood Trump and anti-vaccine movements. All because one person didn’t have his cup of coffee or slept poorly the night before after reading the wrong YouTube comment.

    Take a look at how Musk operates. Dude throws tantrums worth millions on the regular. He bought Twitter at least partially out of spite ffs.

    wolfpack86 ,

    Except we keep electing dick heads who literally don’t want to take his money.

    qooqie , to news in Melinda French Gates, going solo, aims to influence reproductive rights in the U.S.

    I don’t really care the political affiliations of our oligarch overlords even if for the moment they align with mine. Having enough money to sway the country noticeably at the polls is scary af

    disguy_ovahea , to news in Smoke exposure from California's wildfires linked to 52,000 early deaths, study says

    It’s important to be aware of the air quality in your area, especially for those with breathing conditions.

    gispub.epa.gov/airnow

    jeffw OP ,

    Even without breathing problems, you need to watch out when your area gets an air quality warning. The AQI in my area went over 400 last summer because of the fires and you could feel it when you breathed outside.

    FuglyDuck , to news in Smoke exposure from California's wildfires linked to 52,000 early deaths, study says
    @FuglyDuck@lemmy.world avatar

    https://lemmy.world/pictrs/image/5b43db3f-5ed9-4cbf-b00e-8cc62897bd7c.jpeg

    The particulates involved are going to increase cancer incidents as things go forward.

    Whirling_Cloudburst , to news in CDC endorses prophylactic antibiotics to reduce STIs in high-risk groups

    What about the risk for making more super bugs? I hear antibiotic resistant gonorrhea and chlamydia are on the rise in those very groups of people.

    mipadaitu ,

    Antibiotics are complex. Often it’s underutilization of antibiotics that causes problems.

    It’s entirely possible that specific, targeted antibiotics, used with the proper doses will not cause super bugs.

    Whirling_Cloudburst ,

    Prematurely discontinuing use can be a problem.

    TipRing ,

    The article addresses this concern. Doxycycline so far hasn’t produced resistance in PEP users but health officials need to monitor the situation closely.

    apfelwoiSchoppen , to news in Many docs who tweeted product endorsements also took money from manufacturers, analysis shows
    @apfelwoiSchoppen@lemmy.world avatar

    My primary care doctor once tried to sell me MLM vitamins, I reported him to the state medical licensure office. 9 months later I had a new doctor. This is a great system working as intended.

    Cosmonauticus , to news in Many docs who tweeted product endorsements also took money from manufacturers, analysis shows

    And doctors wonder why they’re not trusted sources of medical knowledge anymore. You don’t know if you legit need medication or they got a golf trip to push x amount of pills

    ogmios ,
    @ogmios@sh.itjust.works avatar

    Don’t let them memory hole the opioid crisis.

    Hobbes_Dent , to news in Many docs who tweeted product endorsements also took money from manufacturers, analysis shows

    I truly wish Americans get the universal* healthcare they deserve.

    This is not surprising at all to read the headline of. It’s a for profit healthcare system.

    • Nothing is perfect but I seriously don’t think many Americans understand what’s being kept from them in the name of commerce.

    ib4 some Canadian claims that our shortcomings are worth arguing for private healthcare.

    Edit: whee markdown

    otp , to science in Embryo loss is integral to IVF. Alabama’s ruling equating embryos with children jeopardizes its practice

    I’ll start taking Alabama seriously when their KFCs start putting fried eggs in their buckets with the rest of the chicken.

    “What’re y’all complaining about? You got a WHOLE chicken, not just a few wings and legs!”

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