Let’s not conflate the business side of pharma and the science is pharmacology. The main reason we don’t have new antibiotics is mostly due to the evolutionary arms race against bacteria that quickly develop resistance typically within a year.
No conflation. It’s both. It’s because everything is privatized / sacrificed on the altar of capitalism. Yes, bacteria evolves quickly, but that doesn’t explain the huge gap in development efforts. It’s a complication, definitely. But, I reject the idea that this is the primary reason. More like an excuse.
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How could they possibly derive profits from drugs nearly wholly theorized and funded through government grants? Think of the shareholders and their inability to siphon your taxes into their pockets! Think about them often, especially when you pass by their offices visible through brittle glass. Let them know your feelings.
They aren’t wholly theorized and funded by the government.
By far the most expensive step of drug development is the phase 3 clinical trial, the final stage before a drug can be released. The government doesn’t fund those at all. Government mostly funds pre-clinical trials (ie in animals or tissue culture) which are way cheaper.
The average government grant for a biomed research proposal is nearly $600,000.
The average phase 3 clinical trial costs $20 million.
The NASA and SpaceX relationship is just fine. There’s no real rush to bring them back, the ISS can accommodate them just fine.
This was always going to be the outcome as soon as there was a question about safety, regardless of what they said publicly. NASA has lost 14 astronauts due to poor managerial decisions throughout the Shuttle program. They don’t want to get near that if they don’t have to, and there have been alternatives since day one thanks to the Commercial Crew Program (and of course Russia/Soyuz if absolutely necessary).
I had a bad experience on AirBnB. Had tickets to see a band downtown Asheville. Labor Day Weekend. Found an airbnb in walking distance at a reasonable rate. Booked in April. Day before the stay, got a notice the host cancelled. No explanation. By that point it was $400 a night before taxes and parking for a hotel room downtown. Wound up not going. Ruined my weekend. Never again.
And zero penalty for the host. They only need to claim property damage. I’ve been burned twice by this, and once drove up anyway and the host rented it out on a diff platform for 3x. I played stupid and the guy told me he rented it through vrbo, the day before. I showed him my reservation that now showed canceled as of the day before.
The nice part is that they had two options. They couldn’t prove the safety of Starliner completing the crew test flight, but it’s good that there are 2 commercial crew vehicles that they could have chosen. That kind of choice is what the commercial crew program is all about.
Airbnb is a fine example of a sort of variation on enshittification.
The way it works is a new company with a new and notably cost-effective way of doing things comes along and is unsurprisingly wildly successful. And then, inevitably, that leads to them hiring a whole raft of executive parasites who all have to be paid obscene salaries for doing nothing of any real value, which means the company needs to raise prices and cut back on services in order to generate more profit to pay those salaries. And meanwhile, the new executives, with nothing of any note that they actually need to or even can do, but with a need to create some illusion that they’re necessary, have pointless meetings in which they propose and wrangle about and eventually approve and implement new policies and new plans that are generally awful.
And pretty quickly and not coincidentally the new company ends up at least as bloated, mismanaged, overpriced and under-performing as the companies they so recently replaced.
See also: Uber, DoorDash and the entire streaming industry.
While you got the effects correct, you got the process wrong and that’s important.
The way it works is a new company with a new and notably cost-effective way of doing things comes along and is unsurprisingly wildly successful.
The business model isn’t based on cost effectiveness. Most of these companies work at a loss for a long time, providing artificially low prices in order to gain market share and push existing players out. This is isn’t new. It’s called dumping. Irs just been a bit obscured by buzzwords like “new technology” and “disruption.”
And then, inevitably, that leads to them hiring a whole raft of executive parasites who all have to be paid obscene salaries for doing nothing of any real value, which means the company needs to raise prices and cut back on services in order to generate more profit to pay those salaries.
These executives aren’t hired to do nothing and collect high salaries. Their salaries aren’t what drives the price increases. The major shareholders who spent their money to sustain the company so far want to get return on that money. They install executives with this one goal - maximize profit - so they can get this return. This is what drives the hiring of sociopaths who drive prices up in order to increase profits at all costs. This is what drives hiring such people in all public corporations. You got the effects right but the reasons aren’t to do with shit execs and their salaries. It’s all to do with major shareholders search for growing profits. Everything else follows from there. This is important to understand in order to point the finger in the right direction. Misdirecting people’s substantiated anger with the system has been a perennial tool used to maintain profit maximization for as long as possible.
I stopped doing airbnbs a few years ago. Hidden fees, unreasonable rules and requirements. And now more expensive than most hotels. They just are worse now.
Yeah it turns out that Airbnb hosts behave much more like hivemind landlords than business owners. They all wind eachother up to behave the same in their forums and chatrooms. The advice on how to operate comes from other greedy reactive people and not from like consultants and data mining and people with degrees in their own field like it does with hotels and large businesses.
Airbnb hosts are “school of hard knocks” TikTok and Instagram advice listening get rich quick schemers who put minimal investment into quality.
Both groups are enshittfying their industries. But the downward slope is much steeper in airbnbs than it is in hotels.
I stopped using air bnb. I use to use them for more obscure places that didn’t have hotels. I don’t like they take homes out of the market. I get for vacation areas this is less of an issue but for places like ny city, San Francisco, etc it’s taking homes out of use.
The original model I liked. You have an adu? Rent it for spare cash. Rent a spare room. Etc. it didn’t impact supply and let a lot of people earn a little cash. It wasn’t a business. It was an accessory. Now it’s a business.
The thing is, it was never the original model. It was what was marketed at us. The model was always dumping to monopolize the market. Perhaps the original software nerds didn’t have that in mind but the moment MBAs came along to “help them grow” the program was to win Monopoly in that market. And that was very early on since VCs were involved nearly from the get go in most of those cases. The original idea as you describe it ends at the singing of the VC contract.
PS: Software nerd myself that used to drink the Koolaid, now a very senior, jaded software nerd.
It was the model for a very long time. It was all about renting excess capacity. It was a brilliant move. It wasn’t till much more recently people turned it into a business by buying properties just to air bnb.
Not sure when do you refer as recently but where I am this has been a common practice since at least 2015.
Don’t get me wrong, if you wanted to make a spare rooms rental system, nonprofit or otherwise, you could. But if you wanted to do that you would put restrictions and hoops to jump in order to limit rental to spare rooms only and maybe you wouldn’t charge 17% in fees.
Perhaps the original software nerds didn’t have that in mind but the moment MBAs came along to “help them grow” the program was to win Monopoly in that mark
So…… it was the original model. And yeah airbnb literally grew because of renting out extra rooms, it didn’t grow from turning entire homes into rentals. It became that much much much later.
I get for vacation areas this is less of an issue but for places like ny city, San Francisco, etc it’s taking homes out of use.
It’s every bit as big of an issue for vacation areas / areas where tourism is the primary driver of the economy.
Take Tahoe or Mammoth Lakes for example: until the early 2010s it was still possible to move there without knowing anyone or having any other inside track, get a job (not your favorite or first choice, usually, but something to work from while you get established) and find your crappy first apartment or half-a-cabin or rundown shack or basement or ADU to rent.
That scenario is almost completely gone now and has been for ten years, plus or minus – depending on where each person sees the line that divides difficult from impossible. People making far less than a living wage now commute to both of those areas from an hour or more away. The sense of how “connected” or privileged one has to be to make it or even just scrape by in areas such as these has relentlessly risen to a level that has had an enormous impact on mental and emotional health and life outcomes in these areas too.
All of these factors were already big in the negative column balancing the very real positives of living so close to nature and preferred sporting activities, before the rise of the short term rental blight. But nowadays those negatives are practically off the meter.
Nope, this is the issue for housing in small towns/touristy areas. Most of the housing stock in our town has been scooped up for Airbnb/VRBO/etc, and has 1) limited housing stock for locals, 2) has raised housing purchase prices to unaffordable levels because of “profit potential”, and 3) limited availability of long term rentals that has also shot rental rates through the roof. In small towns, housing is already limited by geography, and so it just exacerbates an existing problem and completely screws local who likely don’t make a lot to begin with, because generally tourism and tourism-adjacent industries makes up the bulk of the available jobs.
I was only ever interested in these company’s services as a way to save money. They are no longer cheaper than a hotel, so I would rather stay at a hotel.
That describes my family. We’ve done Airbnb and VRBO, but now pretty much stick to hotels. You know what you’re getting, price is competitive, to bdint have to wash your own bedding, and a lot of hotel workers are unionized. That’s all in addition to the awareness that every Airbnb house could be a home for someone who needs it. I won’t be sad if the Airbnb model folds and helps the housing market regain a bit of sanity
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