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holycrap

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holycrap ,

They have hundreds of billions in assets, sadly. They’re not going anywhere.

MIT's Innovative Implant with Built-In Oxygen Generation Set to Transform Diabetes Care (www.theinnovativehorizon.com)

MIT engineers have developed an implantable device for Type 1 diabetes treatment. The device contains insulin-producing cells and self-generates oxygen by splitting bodily water vapor. Promising results in diabetic mice show stabilized glucose levels. This advancement could eliminate daily insulin injections, offering a...

holycrap ,

I wonder why they don’t use the oxygen carried by the red blood cells instead of producing their own. I’m guessing this way is just easier from a technical standpoint but it seems more energy intensive.

I totally forgot how terrible a non-ad-free YouTube experience is

So I’ve been using youtube ad blockers since pretty much when ad blocker extensions were first available. Lately though I’ve been getting hit more and more with these messages that YT was sending out every 5 or so videos telling me that adblockers aren’t allowed. No problem, just gotta wait 5 seconds to x it out and then...

holycrap ,

That could feed a lot of cats

holycrap ,

This was awesome. Thank you

Former soldier searched Google, Reddit for spying tips, prosecutors say — Investigators say they found a document on the man's computer titled: “Important Information to Share with Chinese Governme... (taskandpurpose.com)

Former soldier searched Google, Reddit for spying tips, prosecutors say — Investigators say they found a document on the man’s computer titled: “Important Information to Share with Chinese Governme…::A document titled “Important Information to Share with Chinese Government" was allegedly found on the former soldier’s...

holycrap ,

The spies that are this stupid are the ones that get caught.

holycrap ,

Sex joke. “Eating out” is just slang for cunnilingus.

holycrap ,

The people tasked with making them smaller care. To the extent that it impacts their paycheck anyway.

holycrap ,

Some people say pspsps when calling their cat.

holycrap ,

The vast majority were not! Larger animals are more likely to be fossilized, so our fossil record is biased toward larger animals.

holycrap ,

Alas, poor Warwick.

holycrap ,

Seems legit

holycrap ,

– my dog

holycrap ,

Bonus points if the flag is the wrong country for the anthem playing

holycrap ,

If lemmy has taught me anything it’s that people are fucking depressed

holycrap ,

What alternatives are there?

holycrap ,

“We’re looking for losers with no future”

holycrap ,

Didn’t walmart try this years ago?

Armenian president admits 'strategic mistake' in trusting Russia as country moves towards the West (www.cnn.com)

The arrival of US soldiers for a peacekeeper training exercise in Armenia has rankled the Russian government, which has for decades acted as the sole security guarantor for the former Soviet republic. The 10-day “Eagle Partner” exercise, which began Monday, involves 85 US and 175 Armenian soldiers and aims to prepare the...

holycrap ,

Don’t be so hard on Ukraine. they’re addressing their nazi problem one dead Russian at a time.

holycrap ,

I wonder how many of those people remember that

New Vaccine Can Completely Reverse Autoimmune Diseases Like Multiple Sclerosis, Type 1 Diabetes, and Crohn’s Disease (scitechdaily.com)

Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) have developed

holycrap ,

I’ve been following cures like this for years. There are three candidates in phase 2 trials right now that appear to work, they’re mostly figuring out the doses needed and there’s a big question on how long they last. Hopefully permanent but we don’t know for sure.

Diabetics have just been so beaten down by this whole thing. I was told the cure was 10 years away 40 years ago. Even if the technology described here works we could be another 15 years before we see it. Researchers said it could be here as soon as 5 years, which is true if unrealistically optimistic. I believe the cure is coming but I’m not holding my breath until I’m actually in front of a doctor about to receive the cure whatever it happens to be.

holycrap ,

That’s the holy grail for this type of research. Autoimmune cures are seen as a stepping stone for that

holycrap ,

You actually can, that’s the easy part surprisingly. The hard part is keeping the body from killing beta cells after you induce their growth which is why it’s not cured yet.

holycrap ,

I’ll come back in a few hours when I’m on my computer and give you the list. I’m sure others will be interested in it as well.

holycrap ,

A few people asked for more information about these trials that I referred to above. In theory if you can cure one autoimmune disease you should be able to use the same method to cure any of them. Obviously we don’t know that for certain and diseases like Diabetes has the extra step of inducing the growth of new beta cells to produce insulin (more on that below)

That said, the three trials I referred to are Celiac specific. I have this and T1D so those are the two I’ve been following most closely, but I definitely dive into news on ms or any of the other autoimmune diseases.

Note: all of these entered phase 2 this year. They are in the EARLY EARLY stages of that phase, so we should see results in 2025/26 for these. I am also ignoring any trial not in phase 2. Also note that several diabetes and ms cures are essentially variants of these, and many of them are running in parallel.

KAN-101: This is from Anokion and happens to have a trial in my area, hence it’s the one I know the most about. This one works by targetting the liver where the relevant immune cells are produced. Even in their phase 1 trial they found that patients had a dose dependent reduction in IL-1 (a cytokine that your body releases in the presence of gluten if you’re celiac). As with all these trials they need to determine what dose is needed to be a full cure and is it permanent?

TAK-101: This is an MS cure that was adapted for celiac disease, originally developed by ImmunisanT. They also have several other variants of this one, including T1D. Unfortunately their website seems to be down. Takeda is handling the clinical trials here and last I heard they’re waiting for the celiac results before pushing forward with the others, but they expect them to move quickly at that point. Here’s a video by one of the researchers behind this.

TPM502: I know the least about this one, it’s from Topas Therapeutics and they recently announced the start of phase 2 trials in Finland, Norway, the Netherlands and Sweden. [more]

I should emphasize that there is no guarantee any of these treatments will work and everyone is tired of the latest “breathrough” that we never hear about again. Some of the trails above had to go back to the drawing board after hitting phase 2, TAK-101 is a newer generation of “Nexxvax” which if you google that you’ll find articles about its cancellation.

Then Diabetes has the problem of beta cells needing to be restored or replaced. That’s looking feasible either by transplanting adult cells, stimulating the growth of new ones using stem cells or a similar concept. One proposal hides the beta cells from your immune system entirely inside a scaffold. That last one is more of a new treatment than a cure, but it definitely beats what we have now.

The good news is that work IS being done in this area, progress is being made, and I know at least with KAN-101 they have demonstrated it showing results. The cure is coming. Even if most or all of these trails fails the fact that they’ve seen the results that they have is still really good news.

Again, it’s coming. It’s just not in a hurry.

holycrap ,

I responded to my own comment above with more info, check it out here: lemm.ee/comment/3624282

holycrap ,

I posted more information above in this comment: lemm.ee/comment/3624282

TAK-101 is a celiac variant of a (currently paused) MS vaccine. I linked a video on that in my other post that may interest you. The video predates the decision to focus on just one disease. Basically the first iteration of their technology wasn’t effective, but based on the theory that if it works on one autoimmune disease it should work on all of them, they’ve switched their focus to celiac because it’s easier to test the efficacy. Just measure the amount of IL-2 during a gluten exposure. Also it’s cheaper to run one trial than the 5 they had before for various diseases.

The good news is progress is being made on this. But don’t expect it any time soon until you can actually book an appointment to get the procedure.

holycrap ,

Looks like they’ll be available next week.

holycrap ,

You have to take those seriously unfortunately.

holycrap ,

Depends on its policies.

holycrap ,

So is this another zwave or zigbee alternative?

holycrap ,

I wish I was a well connected idiot 😞

holycrap ,

MERICA!

holycrap ,

I’m sure this is exactly how Europeans react to getting stabbed

holycrap ,

You also lose your health insurance. You know, the American way to prevent protest.

holycrap ,

I, too, would use this chair to feed tacos to my dog.

holycrap ,

Some probably do

holycrap ,

Naw, they’re going to shit in their neighbor’s yard as god intended. As the golden rule states, do unto others before they do unto you.

holycrap ,

I’m in the US and drive manual.

holycrap ,

Because the artist doesn’t know how to draw kids I assume.

holycrap ,

Sounds like a waste of real estate

holycrap ,

I really hope this influences future star trek shows.

holycrap ,

With Jesus all things are possible.

holycrap ,

I assume if it’s being reported then it’s because Russia knows already

holycrap ,

Not coincidentally none of the space agencies out there that are capable of this would find it worth their time to launch a mission just to teabag another nation.

holycrap ,

None of the space agencies in the 1950s would be capable of landing gently on a crashed spacecraft.

In the 1950s they had the interest but not the capability. Today they have the capably but not the interest.

holycrap ,

Do consumer friendly phones exist at this point?

holycrap ,

As long as they limit the passengers to people with a net worth of 100 million or higher, then I think this should be encouraged.

holycrap ,

Productivity skyrocketed when we implemented work from home. Employee retention also improved. Keeping it was a no brainer.

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