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Clinical relevance of miRNAs as biomarkers is growing due to their stability and detection in biofluids. This study has identified miR-519a-3p as a potential early biomarker for Alzheimer’s, linked to prion protein expression. This molecule is directly associated with the expression of the cellular prion protein located on the...
This study focuses on the manipulation of the plexin-B1 protein to enhance the brain’s ability to clear amyloid plaques in Alzheimer’s disease, opening avenues for future therapeutic strategies to potentially halt the progression of the disease...
This study has identified the anterior cingulate cortex (ACC) as a key area in the brain responsible for sensory hypersensitivity in autism spectrum disorders. Utilizing a mouse model with a Grin2b gene mutation, heightened neural activity and connectivity in the ACC was observed. Suppressing this hyperactivity normalized the...
A cohort study found that individuals who engaged in mentally stimulating jobs during their 30s to 60s were less likely to develop mild cognitive impairment (MCI) and dementia after turning 70, highlighting the importance of cognitive stimulation during midlife for maintaining cognitive function in old age. [It is important to...
The engineering of artificial cells requires a reconfigurable cytoskeleton that can organize at distinct locations and dynamically modulate its structural and mechanical properties. This study combines peptide self-assembly with DNA programmability to realize a synthetic cytoskeleton in droplets showing that programmable...
Brief anger can temporarily impair blood vessel function, potentially heightening heart disease and stroke risks, finds new study in the Journal of the American Heart Association.
This study describes the identification of an antibiotic class acting via LpxH, involved in lipopolysaccharide synthesis having potent in vivo efficacy against bloodstream infections caused by the critical Gram-negative pathogens E. coli and Klebsiella pneumoniae. Further development of this class of antibiotics could make an...
Scientists have identified a new hybrid brain cell, sharing attributes of neurons and astrocytes. These cells can release neurotransmitters and may influence conditions like epilepsy and memory consolidation.
This study attempts to identify the “protective” genetic factors that can modify or reduce the effect of APOEε4 on Alzheimer’s disease risk and to identify new pathogenic mechanisms, proteins, and pathways that inform development of therapeutic targets and diagnostics....
This study reveals how life’s complexity could originate from simple RNA molecules on early Earth. Through experiments demonstrating RNA’s recycling and replication abilities under conditions such as low salinity and high pH, the research suggests life could emerge from minimal molecular sets in environments akin to volcanic...
This study shows that a ketogenic diet slows early Alzheimer’s memory loss in mice, in which the molecule beta-hydroxybutyrate (BHB), plays an important role thus offering hope for its application in human ageing and cognitive health....
This study has used publicly available MS/MS spectra for bile-acid-selective ion patterns to identify thousands of polyamine bile amidates. It highlights the existence of many more bile acid modifications than previously recognized and the value of leveraging public large-scale untargeted metabolomics data to discover...
This study uncovers that activation of endogenous retroviruses affects prion-like spreading of proteopathic seeds. It supports that endogenous retroviruses play a role in protein misfolding diseases and suggest that antiviral drugs could represent promising candidates for inhibiting protein aggregate spreading....
Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight. There is ongoing debate about the mechanisms that mediate metformin’s effects on energy balance. This study shows that metformin induces the formation of hunger-reducing metabolite N-lactoyl-phenylalanine (Lac-Phe), a byproduct of muscle...
Breast cancer diagnoses in women under 50 have increased significantly in the past two decades, primarily driven by estrogen-receptor positive tumors. This research highlights the importance of early detection and the need for prevention strategies. Prevention efforts in young women need to adopt a targeted approach to address...
This study demonstrates, for the first time, the successful integration of cyanate into a perovskite solar cell to develop a cutting-edge triple-junction perovskite/Si tandem solar cell,proving cyanates to be viable substitute for halides in perovskite-based solar cells. An efficiency of 27.1 percent was achieved....
This cohort study analyzing data from 247 867 adults in the UK Biobank found that individuals sleeping less than 6 hours daily had a notably higher risk of developing T2D compared with those with 7 to 8 hours of sleep. Despite the association between healthier diets and reduced T2D risk, the increased risk associated with short...
cross-posted from: slrpnk.net/post/7419366...
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This study has established specific ultrasound parameters in the use of low-intensity, low-frequency ultrasound stimulation (LILFUS), designed to mimic the brainwave patterns of theta and gamma oscillations observed during learning and memory processes to induce predictable and long-lasting changes in brain function....
This study shows that Individual neurons coordinate to produce rhythmic waves that propel fluid through dense brain tissue, aiding the removal of debris from the brain. Understanding the process can help in neurodegenerative diseases....
