β-Arrestin recruitment is a ubiquitous mechanism of negative regulation of GPCR signaling, which has been demonstrated for almost all GPCRs. Recently, β-arrestins have been shown to act as signaling scaffolds for numerous pathways, such as Akt, c-Src, and ERK 1/2, in a G protein-independent manner. G protein and β-arrestin...
Histological staining plays a critical role in the visualization of tissue and cell structures. Living cells or fixed cells have very few inherent colors and only very small differences in the refractive indices of their component parts. By staining tissue sections, pathologists and researchers can view tissue morphology...
Amine-reactive dye CFSE (carboxyfluorescein diacetate, succinimidyl ester, also known as CFDA-SE) is widely used in cell proliferation and in vivo cell tracking. CFSE is non-fluorescent until it enters viable cells, where it is hydrolyzed by cytoplasmic esterase enzymes to release fluorescent amine-reactive dyes. These dyes then...
cross-posted from: lemmy.world/post/1750098...
I want to run two instances of Stremio in my Nvidia Shield TV which is running Shield Experience 8.2.3 but I don’t know if it is possible to create a duplicate of it....
Hello, i recently uninstalled mangohud because i couldn’t figure out why 32bit mangohud wasn’t working at all. i tried to compile it again with 32bit and now every time i try to launch a game that runs proton it just opens for a few seconds then crashes immediately. The only game that ran with mangohud was a linux native...
Love her to death, but she sleeps like a weirdo. This is one of like a dozen weird ways she sleeps
Like, to make folders/categories/collections of them so you can collapse groups in the sidebar?
Retro Gaming Enthusiast...
I joined Facebook years ago not long after it took off from its college roots. I also quit it years ago when my feed became full of junk....
I am very green when it comes to private trackers, but understand there are strict expectations on members in terms of seed ratios, etc....
Even though the sound coming from my head is totally analog.
I’m not even religious, I just want to know.
Hate Ezra Miller? Watch it for Keaton’s Batman.
Of course, I had to join :)
Help me, help me make it go.
Hello everyone! Here is another one of our threads where we give feedback to you & expect feedback back. Let’s keep building an amazing space together!...