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Can THC Turn Back The Clock? Cannabis Reverses Brain Aging, Boosts Mental Capacity, New Study Suggests

Initially, THC boosted brain metabolism and synaptic protein levels, indicative of heightened cognitive processes. Subsequently, it shifted towards reducing metabolic activities in the body akin to the effects seen with caloric restriction or intensive exercise, known for their anti-aging benefits.

southsamurai , (edited )
@southsamurai@sh.itjust.works avatar

The publication itself, which seems to be legit, and well done.

Haven’t had a chance to read all of it, but it isn’t badly executed by a quick scan.

Edit: I’ve had a chance to read it in full.

About half of it is over my head. Just don’t have the biochemical background to be able to interpret much of the metabolites they were measuring.

That being said, that stuff isn’t actually important for casual interest.

Here’s the key points I found:

First, the study was mice only. While mice are excellent for this kind of work, you can’t guarantee things will be a 1:1 result in Holland p.

Second, the study was for low dose levels, and only delta-9 thc, with no other cannabinoids being used at all.

Third, the study was relatively short, with 42 days being the longer end.

Fourth, and this is the cool part, changes in the relevant metabolites and brain samples had benefit at the 14 day mark. So, if this does translate to human effects, short term, low dose use of delta-9 may be a valuable option. That’s years away before this could be confirmed as valid for humans, but the effects were significant.

All of that means that just smoking weed, you aren’t going to duplicate the conditions of the study. If you’re taking in enough to get high, you’re at a higher dose than the study, and that may cause an opposite effect long term.

This is a very focused experiment, with well defined limits and goals. The information gained can not be used as an indicator that smoking herb as an adult human will give any benefit, much less what is in the title of the article.

Think of this study as step one in maybe ten steps you get to the point where it would be useful for indicating benefits in humans, assuming everything went right along the way.

Icalasari ,

I am glad you linked that, because the article and site itself did not inspire confidence

Angry_Autist ,

Why wouldn’t you look for the study itself in ANY article like this? It’s literally linked 1/3 of the way down the actual article.

Icalasari ,

The very opening basically repeating the name of the college twice and the stocks at the top had me immediately back out of the article as it came across as effectively trash. I then looked at the comments here and was surprised there was an actual publication linked

Angry_Autist ,

Part of the reason our world is in the shit it is right now is people like you more focused on appearances than content. And the worst part is you don’t even consider it a personal failing.

Thorny_Insight ,

I like hearing this so it must be true

Angry_Autist ,

It can also be true independent of one’s liking it.

That little aphorism you just trotted out is a thought terminating cliche, something that contributes nothing and artificially ends discussion.

You chose it deliberately to denigrate the study with zero evidence, and 11 people agreed with you.

Disturbing for lemmy.

Lost_My_Mind ,

Found the basis for CNN and Fox News retaining viewership!

sinceasdf ,

Lmao benzinga the pinnacle of science news

There is a real study it’s referencing at least but these fucks are probably just trying to pump weed stocks

MonkderVierte ,

Nah, that just means it rewires stuff because of the experience.

Boomkop3 ,

Another drug that increases metabolism, protein, etc is cocaine. I have hunch these researchers already know what answer they want and are making crappy arguments to confirm themselves

weariedfae ,

I wonder if micro dosing can give the same effects? I am a control freak and don’t like to be high but worry about cognitive decline. Especially since I got long covid and fucked up my olfactory system. Brain damage sucks.

Angry_Autist ,

Most days I microdose by diluting extract in glycerine, roughly 1/4 of a joint paced out thru the day.

Works wonders for my EDS, and I don’t feel high at all and have a ton more executive control.

Can’t really reply on the cognitive decline but I’m pushing 50 and still in the top .5%

Long Covid did drop me a bit tho, but I guess when you start with a straight eight, losing two cylinders isn’t so bad.

LustyArgonianMana , (edited )
@LustyArgonianMana@lemmy.world avatar

It would be better to microdose lithium if you really don’t want to be high imo. 5-20mg range, can be intermittent (doses for bipolar are in the 100mg range and up). There’s already lithium in some water supplies and in foods like potatoes, so a small amount in a microdose normally doesn’t affect anyone negatively.

www.ncbi.nlm.nih.gov/pmc/articles/PMC10227915/

www.ncbi.nlm.nih.gov/pmc/articles/PMC8324565/

www.ncbi.nlm.nih.gov/pmc/articles/PMC10994667/#:~….

I will say over time your body will adjust to cannabis so if you microdose at night consistently before bed, you’ll just sleep it off anyway and eventually it won’t even get you high anymore.

southsamurai ,
@southsamurai@sh.itjust.works avatar

The actual paper published is about smaller doses.

Grass ,

I’m not convinced. Unless the idiot stoners in my area are so fucking stupid that even when you work some science magic to make them smarter, they are still about as intelligent as a sack of dirt.

RobotToaster ,

Maybe it de-aged their brain too far?

fsxylo ,

Same energy as “wine is good for you!” As it turns out, no. Wine is absolutely poisonous to you.

OsrsNeedsF2P ,

But taking 30 minutes out of your day to relax and unwind? That’s good for you.

HorseRabbit ,

Is that why people that smoke every day act like fucking children?

LustyArgonianMana , (edited )
@LustyArgonianMana@lemmy.world avatar

Reefers 🫧

https://lemmy.world/pictrs/image/8f4f3830-0896-4f90-9e6a-653cf73d10f5.jpeg

Eta: lol the downvote is even funnier

LustyArgonianMana , (edited )
@LustyArgonianMana@lemmy.world avatar

No wonder Cheech&Chong, Willie Nelson, Snoop, and Lily Tomlin seem pretty young at heart/mind for their age

ivanafterall ,
@ivanafterall@lemmy.world avatar

I voted for this because I want it to be true. Yay, science!

Angry_Autist ,

never really expected so many prohibitionist shitbags on lemmy. Off to the blocklist you and your ilk go!

ThePantser ,
@ThePantser@lemmy.world avatar

Idk, I’m high right now and my memory is shit.

ohYouKnow ,

Is this why you posted the same comment twice?

Once here

And the other here

ThePantser ,
@ThePantser@lemmy.world avatar

What? Maybe your app is broken, those links are the same.

yokonzo ,

Or is it?

ohYouKnow ,

https://lemmynsfw.com/pictrs/image/ce382e41-d2f6-40bb-8607-2e1eca7d3154.gif

Sanctus ,
@Sanctus@lemmy.world avatar

Bro is doing PI work on the horny account.

intensely_human ,

That’s what they mean by reversing brain aging

Phenomephrene ,
@Phenomephrene@thebrainbin.org avatar

Younger brains have fewer memories. This checks out.

voracitude ,

I didn’t know you can monkeys paw science

Drunemeton ,
@Drunemeton@lemmy.world avatar

The monkey was equally surprised.

CaptainSpaceman ,

Short term vs long term

Angry_Autist ,

I started getting high later in life (25) and had shit memory beforehand.

It’s a bit less shit now, take that as you will.

workerONE ,

When I was 17 I really turned back the clock. Almost every day we were reversing brain aging and boosting mental capacity.

remotelove ,
@remotelove@lemmy.ca avatar

It would explain the poor memory I get when I smoke. You can’t remember something that hasn’t happened yet, so it naturally increases your ability to remember more. (Taps forehead…)

Angry_Autist ,

it’s all the training on remembering where the fuckdamn lighter is…

TSG_Asmodeus ,
@TSG_Asmodeus@lemmy.world avatar

There’s also this study from 2017, if you want more info on this.

AlecSadler ,

It’s amazing to me that they misspelled “reaserch” in the first bullet item.

tyrant ,

It’s turning back to the time before they knew how to spell

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