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Scientists find humans age dramatically in two bursts – at 44, then 60

If you have noticed a sudden accumulation of wrinkles, aches and pains or a general sensation of having grown older almost overnight, there may be a scientific explanation. Research suggests that rather than being a slow and steady process, aging occurs in at least two accelerated bursts.

The study, which tracked thousands of different molecules in people aged 25 to 75, detected two major waves of age-related changes at around ages 44 and again at 60. The findings could explain why spikes in certain health issues including musculoskeletal problems and cardiovascular disease occur at certain ages.

“We’re not just changing gradually over time. There are some really dramatic changes,” said Prof Michael Snyder, a geneticist and director of the Center for Genomics and Personalized Medicine at Stanford University and senior author of the study.

“It turns out the mid-40s is a time of dramatic change, as is the early 60s – and that’s true no matter what class of molecules you look at.”

solsangraal ,

lol i turned 44 last year and yep. feel like shit all of a sudden

dactylotheca ,
@dactylotheca@suppo.fi avatar

Fuck, that explains a lot

NineMileTower ,

The research tracked 108 volunteers

Not enough to actually mean anything.

fpslem OP ,

Read further in that paragraph:

Researchers assessed 135,000 different molecules (RNA, proteins and metabolites) and microbes (the bacteria, viruses and fungi living in the guts and on the skin of the participants).

Also, see the previous article in Nature linked in the article. That study looked at fewer proteins, but had over 4,000 participants.

Webster ,

I mean, that makes me even more skeptical. 108 volunteers tracked for that many sparesely populated vectors is 100% going to have hundreds of false positives just due to statistical noise.

RagnarokOnline ,

I nominate NineMileTower for a Pulitzer Prize

NineMileTower ,

I’ll take my Nobel Prize now.

SoJB ,

My favorite part of science discourse will always be people self-reporting how little they understand science the math behind statistics by complaining about sample sizes that have nothing wrong with them

NineMileTower ,

Statistics? Statistically speaking they studied 0.00000135% of the population all located in California.

ThrowawayPermanente ,

As a 41 year old, goddamnit

Blum0108 ,

Lol literally my thought.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

Well that explains why I feel like I’m about 80 now that I’m 47.

Someonelol ,
@Someonelol@lemmy.dbzer0.com avatar

Woah there, save something to degrade in another 13 years.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

It’s okay, my mom’s in her 80s and my dad made it to his 80s and their parents all made it to their 90s, so I have a good 5-15 years to degrade once I turn 60.

DefiantBidet ,

48 here… i used to be able to read the freaking copyright date on those eye charts … once i hit mid 40s i need glasses.

FlyingSquid ,
@FlyingSquid@lemmy.world avatar

I just got progressive bifocals. It was nice to be able to read my watch properly again, but not so nice to have to look down whenever I’m going up or down stairs and to have to move my head around all the time to see all the real estate on my monitor since it’s 27".

Bishma ,
@Bishma@discuss.tchncs.de avatar

In less than 2 years (in my early 40s), my eyes went from better than 20/20 with great close up, to barely 20/20 with astigmatism and I need readers

Windex007 ,

The idea that anyone would think that our bodies change at a constant rate is so bizarre to me, having gone through puberty myself (not to brag).

dmtalon ,

Interestingly enough, a random couple things happened when I was between 43-44 that lead to me start distance running and run my first full marathon about 4 months before I turned 44.

I was decently fit before, but didn’t run any distance above a maybe 5 miles. I do not remember anything negative happening around that time or shortly after. I was actually increasing my cardio endurance dramatically over the next 5 years or so.

fpslem OP ,

Good on you, I’ve read elsewhere that the better shape you can be in prior to years of decline, the better you handle the natural aging process. I don’t need to do anymore marathons, they’re too hard on my knees, but running/biking and body-weight exercises are part of my attempt to stave off the inevitable.

dmtalon , (edited )

Oh ya… Marathons have come and gone for me :) Initially because they were just expensive but COVID had me WFH full time and the group I ran with was near my work office. So I sort of morphed into running alone and just as maintenance vs. Training for something.

I’m about to hit 53 and try to run between 15-20/miles a week still but I did fall behind on my fitness the end of last year when I had some crazy back spasms after sneezing (of all things) that really set me back. Takes forever to get back. Luckily I do not have any physical issues (knees etc) most if my issues now are not eating healthy enough and general motivation to improve. Sounds like I’ve got about 7 years to get on top of it so I can cruise through that age too :)

fpslem OP ,

back spasms after sneezing (of all things)

This is the true humiliation of getting older. In my 20s I climbed mountains and had plenty of scrapes and mishaps, but I just shook them off and my body just healed up quickly. Now I can tweak my back with a sneeze or be sore for days just by raking leaves. Life comes at you fast.

dmtalon ,

I literally could not get off the floor for around 2h and was panicking quite a bit. Never ever felt so vulnerable before. Do not recommend whatever happened to me :). Good thing is it was just muscle and once healed I was back to 100% It just prevented me from running for over a month.

Bishma , (edited )
@Bishma@discuss.tchncs.de avatar

This article is reminding me of a study a few years back that suggested that (provided you’re otherwise healthy and able bodied) you can get into any level or shape you want (if you put in the work of course) up until 60-something. Then you hit an age wall where about the best you can do is maintain what you’ve got. Suggesting that countering that 40-something aging event by pre-gaming for the 60-something aging is a smart plan.

nilaus ,

Turned 44 6 months ago. Haven’t felt it yet. Guess it’s going to get rough soon…

moshankey ,

Oh, fuck me! I got nothing else.

Jezebelley ,
@Jezebelley@fedia.io avatar

I only have a couple years left before the old officially sets in it that's the case. Save me...

ben_dover ,

i thought becoming 30 fucked me up enough already… so i have to go through this two more times, only it will be worse? ugh…

Senseless ,

I know what you mean. I make old people noises now, when I stand up from a low couch or sth.

MediaBiasFactChecker Bot ,

The Guardian - News Source Context (Click to view Full Report)Information for The Guardian:
> MBFC: Left-Center - Credibility: Medium - Factual Reporting: Mixed - United Kingdom
> Wikipedia about this source

Search topics on Ground.Newshttps://www.theguardian.com/science/article/2024/aug/14/scientists-find-humans-age-dramatically-in-two-bursts-at-44-then-60-aging-not-slow-and-steady

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ieatpwns ,

So is it kinda like extra stages of puberty?

MNByChoice ,

This is reassuring, even if not true. The mid-40s slide is a bump, not a new slope.

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