If your GPU supports vulkan then vulkan it is, if not, then opengl, examples of opengl usage is older cards or/and nouveau driver, not nvk, and they work on backporting nvk to older cards too so even older Nvidia cards gonna support Vulcan one day, so, use Vulcan if supported
As a programmer, Vulkan is like OpenGL has decided to stop holding your hand and let you spread your wings. Learning curve is utterly brutal, but no more assumptions - you’ve complete control and everything is open to you.
As a user? Install Wine and DXVK, or just Proton that brings everything with it, enjoy everything just working better. Not really a tough decision.