You can only get cocaine from the South American cartels. No local production with vertical integration is impossible. You can only cut into street level as a producer and direct customer interface is the only viable business model. That competition would be a direct with likewise retailers. Yes, buying from the producers of raw material and locally producing the finished good has a considerable profit margin, but your direct competition is established brands that have no problem capping a fool stepping on their block. Distancing yourself from the customer-facing business only decreases profit margin and risk, but unavoidable turnover would mandate a more direct customer interface in order to maximize profit margins by absorbing considerable risk.