The US has wanted to break up or otherwise weaken/isolate Russia ever since almost immediately after the break-up of the USSR. That’s why it’s been expanding NATO ever-closer to Russia despite originally having sworn up & down never to move one inch eastward. The US couldn’t allow a Ukrainian government to stand that was friendly with Russia.
The US doesn’t want Europe and Russia to develop closer ties, because it doesn’t want the “Eurasian landmass” to ever cohere, because then it would become too self-sufficient and powerful for the US to control. Zbigniew Brzezinski laid this theory out when the Soviet Union fell. That’s why the US tried to convince Europe not to build Nord Stream 2 and then later not to turn it on, why Biden said he would “bring an end to it” if Russia invaded, and why they ultimately did bring an end to it.
The US also very much wants regime change or balkanization in Russia so it can resume its neocolonial plundering of it, which started under Yeltsin and ended under Putin. That’s why the US has a special hate for Putin in particular.
The US has been meddling in Europe ever since WWII, and Ukraine has an even longer fascist history.