Eh… TrueNAS UI basically takes care of any zfs learning curve. The main thing I’d note is that RAID 5 & 6 can’t currently be expanded incrementally. So you either need to use mirroring, configure the system upfront to be as big as you expect you’ll need for years to come, or use smaller RAID 5 sets of disk (e.g. create 2 raid 5 volumes with 3 disks each instead of 1 RAID 5 volume with 6 disks).
Not sure what you’re referring to as an easy backup option that zfs excludes, but maybe I’m just ignorant 🙂