I started with paths because I didn’t want to pay for a expensive SSL certificate for each service I’m running (now with letsencrypt no problem anymore). But that turned out to be a terrible idea. Once I wanted to host a service on a different server the problems started. With subdomain you just point your DNS to the correct IP address and that’s it. With paths you have to proxy everything through your one vhost and it get’s really messy. And to be honest most services expect you to run them on the root directory and not a path.