New Alzheimer's Nasal Spray Clears Toxic Tangles in Human Neurons And Mice

witty_username , 21 days ago

I’m convinced that the Alzheimer’s field is one of the areas of research that will be looked back upon with disillusionment.
Tau tangles and beta plaques have been fiercely and dogmatically pursued as causes and therapeutic targets of Alzheimer’s disease. However, it is becoming increasingly clear that these aggregations are likely a consequence of the disease that does not necessarily present an avenue for therapy. I.e. the harmful part of the disease probably acts upstream of or in parallel to the accumulation of the tau and beta aggregations

Snowflake , 21 days ago

All because Sylvain Lesné and team published a fraudulent research paper in 2006. The field has possibly lost a decade of time and money.

amenji , 21 days ago

TIL. Damn.

Reminds me of the how early the covid policies were based on age-old misconceptions about aerosols.

joelthelion , 21 days ago

How do you explain that amyloid-targetting therapies are seeing some success, even if limited?

SineSwiper , 21 days ago

Well, I’m certainly glad there a nasal spray that deals with the toxic mice tangles in my nose.

BackOnMyBS , 21 days ago

If mice ever become the dominant species, they’re going to start off so overpowered with advancements in medical treatments.

figaro , 21 days ago

Man you don’t even know, we probably have immortal mice at this point

srasmus , 22 days ago

I feel like I’ve heard that clearing the tangles really doesn’t affect the trajectory of the disease?

SuperIce , 21 days ago

Yeah, from the article “while many tau-based therapies show promise in animal models, their translation into effective medicine for humans ‘has so far failed.’”.