Scott Kelley did 340 days in space without too much long term damage that I am aware of (his was the first long term test) so I wouldn’t anticipate damage much worse than what he got. If we can get them out in under a year and if they get don’t have an emergency and if they don’t have any underlying medical conditions that get exacerbated and if our single test can be used to predict their outcomes.
We really fucked up. Either trusting Boeing or not having a contingency plan I guess.