Appeasing them could be dangerous depending on how it’s done, and to what extent. But, what if the appeasement is merely choosing a man for her VP? Maybe that’s all it will take.
We cannot and should not cater to the worst people in the room
The worst people in the room are voting for Trump. This is catering to people in the room who are on the fence and might need a nudge. You can stick to your principles and ignore them, or you can consider their opinions. Ignoring them might mean losing the presidential race. And if you lose, then the purity of your agenda and message is meaningless because the other side wins. And, in this election, the other side winning might mean permanent damage to the whole democratic process.