I’m team red on Linux all the way. Ryzen 5 2600 (soon upgraded) + 6750XT. Mesa works out of the box and hasn’t broken yet. The only thing that caught me off-guard is having to manually enable VKD3D for newer DX12 games – I recommend using a launcher like Heroic (very easy, Steam-like front-end for several stores) or Lutris (universal, exposes more advanced options) to manage your games. You should also look at ProtonDB for compatibility and tweaking tips, and Lutris install scripts in case a game needs a specific framework to be installed.
andyburke