Are you using the Steam version or the Rockstar version? Because the former should just work OOTB (unless something has changed recently). The latter can be a pain to get working.
I expected Civilization VI to run fine, and… it did. although anti-aliasing decided not to work.
It has a native version and sometimes they are missing features/performance. Try forcing Proton.
while Win 11 is basically “don’t worry, it’ll run!”
That hasn’t been my experience at all, even with gaming. But YMMV.