If you are pro-active, you’ll just make it easier for cheaters to iterate and experiment and find ways around the pro-active… and what happens then? You’re back to reactive. Not to mention, pro-active anti-cheat tends to be rife with false positives, resulting in very public ban waves against innocent people.
It cant be helped, No amount of giving your butthole over to big daddy game company and their rootkits will make a game cheat-free. all they can hope for is to catch the cheaters, drop the hammer on them in bulk, so they struggle and panic to try and find out how it was detected so you can increase their cycle time before they have a new working one out.