Depending on the hosting of things by the game, anti cheat can make sense. Payday 2, for example, is almost entirely peer to peer in games, and cheats allow you to be quite mean in game, even if you’re not the host.
But I can’t help but think PvE anti cheat is more about locking people out of skins/events/dlc/things than actually being to prevent cheating. Else you could just have a button that invalidated the gains of the cheated match.