I’m currently struggling with Nobara and the growing amount of bugs with each new kernel update.
Otherwise I would have recommended that one, since it offers some great convenient features, like a graphical management tool for all sorts of Wine versions, which can be installed in parallel. The kernel supports fsync and is tuned for low latency. Game performance is decent and I also got all my games and launchers (native Linux and also Wine) working.
For the audio part, there is pipewire, which works like a charm. There is also a compatible flatpack for DSP/equalizer which I couldn’t find it on Ubuntu’s snap store: JamesDSP. Now, after some tuning, my rather flat-sounding headphones sound do super boomy.