I tried this specifically to get Alan Wake 2 to work (with the 3080ti) and it is a less than spectacular experience as most of the effects on the game (shadowy figures, screen distortions, Ray Tracing) do not work properly in comparison to running on windows.
In bazzite-nvidia’s defense, it does just “work” but only to the extent that the Nvidia driver works. This is still more of nvidias issue and less bazzite-nvidia. Regular Bazzite with a 5700xt worked very well.