There is a tech difference with a DualSense controller that other controllers don’t have, and that’s the adaptive triggers. As far as I am aware, they’re the only ones with that. It’s a cool effect. Makes shooting in games feel more like handling a gun than vibration effects do.
Other than something like that, button layout is a choice. Parallel sticks or off-set sticks. Off center buttons. The way the D-pad functions (rolling style like Xbox or just 4 buttons like PlayStation). Etc.