Nobody has mentioned Everything by Void Tools. Find any file in your computer blazingly fast. Make shortcuts to only search certain folder (e.g., search for “notes: python” to find file “python” in your notes folder. Also works for network drives. Some functionality needs admin privileges but most work fine without (hellooo work computer!).
Combine this with Run (Power Toys) or Keypirinha or some other launcher and you can find all files and start all programs with a quick shortcut + short text.
More supercharging by using Fanzy Zones by Power Toys and combining it with AHK for easily controlling virtual desktops and having all windows open where you want them.