That seems like a very powerful medication with a lot of effects and side effects that you would only want to use as a last resort. Wiki says it has effects on serotonin and dopamine receptors, which are also receptors effected by zoloft, so if seroquel helps you then you might want to consider switching to zoloft. But honestly what the hell do either of us know, we're just sharing anecdotes, which is useful but shouldn't be assumed to be true.