“The occupation targeted the convoy in more than one location outside the door of al-Shifa Hospital,” Ashraf al-Qidra the ministry spokesperson said.
He said the convoy was targeted both at the hospital gate and at Ansar Square a kilometer away.
Hamas-run Al-Aqsa television cited the Health Ministry as saying scores of people were killed and injured.
Earlier on Friday, Qidra said ambulances would send critically injured Palestinians who urgently needed care in Egypt from besieged Gaza City to the south of the enclave.
Israel, which has accused Hamas of concealing command centres and tunnel entrances in al-Shifa hospital, ordered all civilians to leave the north of Gaza last month and its military encircled the area on Thursday.
Hamas and al-Shifa hospital authorities have denied the facility is used as a base by militant fighters.
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