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World-first lung cancer vaccine trials launched across seven countries

Doctors have begun trialling the world’s first mRNA lung cancer vaccine in patients, as experts hailed its “groundbreaking” potential to save thousands of lives.

Lung cancer is the world’s leading cause of cancer death, accounting for about 1.8m deaths every year. Survival rates in those with advanced forms of the disease, where tumours have spread, are particularly poor.

Now experts are testing a new jab that instructs the body to hunt down and kill cancer cells – then prevents them ever coming back. Known as BNT116 and made by BioNTech, the vaccine is designed to treat non-small cell lung cancer (NSCLC), the most common form of the disease.

The phase 1 clinical trial, the first human study of BNT116, has launched across 34 research sites in seven countries: the UK, US, Germany, Hungary, Poland, Spain and Turkey.

jupyter_rain ,
@jupyter_rain@discuss.tchncs.de avatar

So are the people who were anti Covid-vaccine also anti-cancer vaccine? Curious how that is gonna turn out.

“No doc, I wanna die an agonizing death, full of metastases, rattling breath, pain in my whole body, like god intended it”.

BossDj ,

My cousin’s friend’s wife got the vaccine, and a month later had an STD even though neither of them had an STD before. Now my cousin has the same STD too because the government is spreading the vaccine through the air now.

jupyter_rain ,
@jupyter_rain@discuss.tchncs.de avatar

So…I got bad news for the marriage of your Cousin.

Chocrates ,

Any idea yet how long it might last? Could this ever be something that we take young (either as kids or now in my 30s) and just not be afraid of lung cancer?

Hazzia ,

Someone who’s more familiar with mRNA technology please explain to me.

I know that mRNA works for viruses because it trains the body on specific protein structures the virus uses to easily identify them, but in terms of cellular organisms like cancer and bacteria where the proteins are hidden behind the cell wall, especially in the case of cancer where it’s not even clear where in the DNA the mutation will take place, how the heck does this work??

Kroxx ,

The jab uses messenger RNA (mRNA), similar to Covid-19 vaccines, and works by presenting the immune system with tumour markers from NSCLC to prime the body to fight cancer cells expressing these markers.

Tumor markers have traditionally been proteins or other substances that are made at higher amounts by cancer cells than normal cells. These can be found in the blood, urine, stool, tumors, or other tissues or bodily fluids of some patients with cancer. Source: www.cancer.gov/…/tumor-markers-fact-sheet

I am not a MD or anything but from what I can tell based on the tumor marker described above it sounds like it would work pretty much the same as the covid vaccine? Maybe the proteins build up like plaque and the mRNA just stops the protein production gene expression? Again I do not know a ton about cancer.

fubarx ,

Grandmother died a while ago of this type of lung cancer. Be great if nobody else got it.

nkat2112 ,
@nkat2112@sh.itjust.works avatar

This is wonderful news! And nice to see BioNTech’s use of mRNA moving forward! Let’s hope things work out well and that they’re able to make it work for other cancers too at some point.

Bob_Robertson_IX ,

Time to buy up stock in Philip Morris!

MediaBiasFactChecker Bot ,

The Guardian - News Source Context (Click to view Full Report)Information for The Guardian:
> MBFC: Left-Center - Credibility: Medium - Factual Reporting: Mixed - United Kingdom
> Wikipedia about this source

Search topics on Ground.Newshttps://www.theguardian.com/society/article/2024/aug/23/world-first-lung-cancer-vaccine-trials-launched-across-seven-countries

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