The U.S. has no doubt Israel will respond whether lives are lost or not. And that Iran itself will be targeted.
My hot take: at least Iran didn’t shoot down its own civilian airliner this time thinking they were taking out a US bomber or whatever. My fear is that Iran thinks it’s ordained by Dog to restore Islam to its rightful place (read: cleanse Israel of all the Jews and and put decent Muslim folk in charge of all the holy piles of rocks), and maybe that means their strategic calculus isn’t exactly sober. Perhaps they think they can win a war with Israel, what with Dog on their side, and they absolutely cannot. Iran has said they are willing to let this wave of attacks be the end of the matter so let’s hope they are sober enough to not keep going blow for blow. So far it seems to be a proportionate response by Iran (given that almost nothing seems to have made it through (though I am not sure what their targets were, specifically)). I’d like to see Iran have a nice Arab spring and see the Supreme Leader get the respect he deserves just like Gaddafi, but I’d be just ducky if it could be a drone strike. Hopefully this doesn’t devolve into utter catastrophe and a cascade of failed states.