That’s an interesting thought. At first I was wondering what would distinguish them from standard anti-aircraft systems, and then it clicked.
They’d have to be fast - at least with the ability to put on a burst of speed significantly higher than that of the target drone. Making it have an explosive increases the damage and potentially area of effect, but if you think about it like the kinetic kill vehicles designed to take out ICBMs, I think you can just whack the target drone hard enough to knock it out while potentially increasing speed, decreasing weight, and decreasing costs.