i dont think its realistic to have reliable anti drone defenses.
i fly an fpv drone (the kind used by ukraine), but for fun and without explosives, and they are so small and manuverable that it doesnt seem super doable to hit them with a net or whatever. jamming would work, but they can just use a different frequency, and gps spoofing is only a problem for autonomous drones.
i dont know enough about lasers to judge them, so maybe thatd work, but as an example of how extreme drones can get, there was a guy who built a little quadcopter that flew up to 40,000ft. its a hard problem