Well, I’m not a big comic reader but that’s what the story with Lex Luthor is about, right? how all of Superman’s immense power is useless against the intelligence of a rich and evil man. I think that is the most famous antagonist and that has transcended the comics the most for a reason. Maybe for fans it’s doomsday or zod, but for casual readers and the general public it is lex and it is for good reason.