It’s super fast and has tons of great features including cutting-edge encryption and several compression options.
It has a GUI and is cross-platform.
It can do both cloud and local/network backups.
That includes locally mounted disks, SFTP, rsync, or any network share/etc accessible from your machine as well as many cloud options.
The de-duplication stuff is also killer. If you upload the same file (or chunk of data) in different folders or even from different systems it will map them to the same backup storage potentially saving you a ton of storage space.
It also uses a rolling hash system so if you modify just a handful of megabytes from a 25GB file many times, only the megabytes of changes will need to be backed up to store the version history. You do not need to store 25GB every time you modify that file.
There’s a ton of other goodies as well!
And it’s all FOSS!
I use it to backup to an external hard drive, a NAS, and to Amazon S3. You can configure multiple repositories like that and have them all run at the same time (subject to their individual scheduling policies of course)