There is quite a significant difference. An ssh server - even when running on a non-default port - is easily detectable by scanning for it. With a properly configured Wireguard setup this is not the case. As someone scanning from the outside, it is impossible to tell if there is Wireguard listening or not, since it simply won't send any reply to you if you don't have the correct key. Since it uses UDP it isn't even possible to tell if there is any service running on a given UDP port.