The way I've got it set up is I have a Nextcloud\Desktop, Nextcloud\Downloads, Nextcloud\Documents, Nextcloud\Pictures, and Nextcloud\Videos folder, and on each machine I use I point each of those points in windows to use the folder in the nextcloud folder instead of my users folder, then I run the official client to sync the entire nextcloud folder. By doing that, whichever computer I'm on I've got the same stuff in my main folders and anything else I have I can keep in the nextcloud folder. I've also got it on my mobile device just to automatically upload new pictures to the InstantUploads folder, but the app is a bit limited.
I live equally on the road working as at home, and I've got completely different computers for home and travel, so in this way I've always got all my files available since once I start up the computer it automatically starts pulling the local files. If you don't want a full copy of everything on both machines, I think you can tell it to just create links of the files and the client will download the files from the server as they're required, but I prefer having a local copy of the files myself.