I assumed that yubikeys would be found pretty much only in enterprise environments but perhaps I was wrong there.
As a datapoint, I am a home user and use Yubikeys. For example, they are one of the 2FA options supported by Bitwarden for home users.
I have recently trialed both NitroKey and OnlyKey to see if I’d want to replace my Yubikey with either of those, but the Yubikey is sadly superior. (Sadly because it’s not as open as those other two options.)