Yes, I’ve got separate subnets & vlans for a few things. My PCs/phone/tablets/etc, homelab, IoT devices (i.e. loads of Govee bulbs/ropes, gaming consoles, oven, etc), Guest (all isolated from everything else internal) and one for my roommate. I’m on a Unifi Dream Machine Pro so setting up traffic rules to allow certain traffic from PC vlan to homelab (and the other way) was pretty straightforward.
As for the VPN, yes a full tunnel would force all traffic over the VPN, but for all but my *arr stuff that’s overkill. I just join all my VMs to Zerotier and force traffic from the public LB in via their VPN IP, but the VMs can still pull yum updates and anything else they want over my WAN link.