Yes, with some big "if"s. NextCloud can work very well for a large organization if that large organization has a “real” IT department. I use “real” to describe how IT departments used to work 20+ years ago, where someone from IT was expected to be on call 24/7, they built and configured their own software, did daily checks and maintenance, etc. Those sorts of IT departments are rare these days. But if they have the right personnel, it can definitely be done. NextCloud can be set up with hot failovers and fancy stuff like that if you know what you’re doing.