There have been multiple accounts created with the sole purpose of posting advertisement posts or replies containing unsolicited advertising.

Accounts which solely post advertisements, or persistently post them may be terminated.

Bransons404 ,

Is this the “T1D cure in 10 years” I was promised 21 years ago?

ICastFist ,
@ICastFist@programming.dev avatar

Call me when the human trials give a positive return

whoisearth ,
@whoisearth@lemmy.ca avatar

Patience Padawan.

I have 1 autistic kid with T1D and 1 kid with celiac. I’m confident in next 10 years both will be cured.

jeremyparker ,

I’m guessing you mean the diabetes and celiac will be cured, not the autism

whoisearth ,
@whoisearth@lemmy.ca avatar

Lol yes. I am not a crackpot

m3t00 OP ,
@m3t00@lemmy.world avatar

news.uchicago.edu/…/inverse-vaccine-shows-potenti…

FrankTheHealer ,

Website I’ve never heard of: check

Wild claims that seem too good to be true: check

Little to no proof about said claims: check

Don’t get me wrong, this would be fantastic if it’s true. But I’m sceptical. It feels like all those articles about a cure for cancer that then never go anywhere.

where_am_i ,

like the good ol r/science

this place is going doooown

m3t00 OP ,
@m3t00@lemmy.world avatar

I see it in google news all the time. spammy but I don’t see their ads. they gave references near the end.

kerrigan778 ,

Here’s the article that should have been posted, except of course that it’s a few months old and nothing new has been reported on it yet that I know of. pme.uchicago.edu/…/inverse-vaccine-shows-potentia…

chaosppe ,
@chaosppe@lemmy.world avatar

Awesome, I have an autoimmune desease that can possibly paralyse me in future. I hope progress can continue 🙏

chemicalwonka ,
@chemicalwonka@discuss.tchncs.de avatar

I took two doses of Pfizer Covid Vaccine and now I have a heart disease.

m3t00 OP ,
@m3t00@lemmy.world avatar

i like how people complain because they weren’t properly spoon fed curated articles selected specifically for them by someone who gaf. 1) be kind - is a reminder to myself

Maalus ,

This comment isn’t kind, it’s obnoxious.

m3t00 OP ,
@m3t00@lemmy.world avatar

thanks for the reminder

Son_of_dad ,

Every science article is just a comment section disapproving the article. That’s why I stay away from these science communities, it’s all clickbait and lies

m3t00 OP ,
@m3t00@lemmy.world avatar

okay then

phoenixz ,

Looks at that… The one thing good about reddit was the /r/science sub, it was always full of moderator deleted comments that were off topic, factually incorrect, etc. posted articles actually were scientific reports and not clickbait crap lik this

corsicanguppy ,

Wait. I read above that this article is good. No?

doom_and_gloom ,
@doom_and_gloom@lemmy.ml avatar

I don’t read as many science articles from lemmy as I did at one point on reddit, but in my experience many of the debunkers were clearly not scientists and were not appropriately assessing the studies based on their scientific context.

For example studies build on each other as a database of knowledge, and every leg that database is built on needs constant re-evaluation in light of new information. But so many people expected a single study with a modest budget to do the work of 20 studies, all in one paper. When they should be reading the other 19 for context, and then determining how the 20th adds to their understanding of the field.

And then, yes, there has always been an amount of clickbait being shared, too. But I’ve seen a lot of fingers pointed at what I would call false positives, personally.

southsamurai ,
@southsamurai@sh.itjust.works avatar

What’s bad is that it’s a good article. It covers things very well

c0mbatbag3l ,
@c0mbatbag3l@lemmy.world avatar

At the same time, commenters don’t necessarily know what the fuck they’re talking about either.

Meowoem ,

Yeah Reddit always had that problem, I think it’s here too - top rated comment is someone saying it won’t work and the article is wrong, everyone just accepts it without question.

I still see people using battery breakthrough stories as an example of stuff that never comes too market despite most of them being in the very phone the person is using.

I genuinely think a lot of them are just people who hate science and engineering so don’t want people to be interested in it

victorz ,

I genuinely think a lot of them are just people who hate science and engineering so don’t want people to be interested in it

So strange for those people to hang out in science communities in that case, to me.

m3t00 OP ,
@m3t00@lemmy.world avatar

a cat group I started the same time as this has 5k more subs and no whining. it is just cat pics. there are a lot of fake science sites to avoid but they all have bills to pay. they expect it to be like reddit junk and all. been to reddit through search results and sometimes found useful threads. mostly not.

Meowoem ,

Yeah, I think they come from the front page, I don’t think you see it as much on more obscure articles.

Xtallll ,
@Xtallll@lemmy.blahaj.zone avatar

I wonder if a similar technique could be used to reduce organ transplant rejection.

Buddahriffic ,

Same but allergies.

southsamurai ,
@southsamurai@sh.itjust.works avatar

Ehhh, maybe? If I’m reading the article right (and I haven’t yet gone digging past the article to the source itself because that takes more time than I currently have), it’s targeting t cells only. Rejection involves more than just t cells though.

It might be at least partially effective, I’m not trained in the field to be able to predict that much, just basing what I’m saying off of past reading and general information.

I’m not confident in this, though. It’s pretty damn far beyond the level of actual training I’ve had. I can say confidently that the basic techniques they’re talking about should be applicable to more than just autoimmune disorders, just not the degree of efficacy.

There’s just so many more cells involved in something like hyperacute and acute rejection that it’s likely to be something that would have to be more complicated than the already complicated technique they’re working on.

I would say that, if this proves to work in actual humans safely and effectively, that the immune related cancers would be the more probable beneficiaries of the method.

See, most of the autoimmune stuff is a “false positive” the body at some point got fooled by some kind of external agent, that happened to match some part of the body. So, if you wipe out the “memory” of that false positive, the body stops attacking itself.

The cancers that are immune related should respond in a similar way. You’d still have the malignant cells, but it should stop new ones from going crazy, and the usual methods of killing off the existing malignant cells should effectively “cure” the person with drastically reduced chances of relapse.

But with transplants, there’s no false positive. There actually are foreign cells in the body, being constantly exposed to immune cells. There’s also usually more than one kind of cell, so the method they’re using probably would need multiple efforts to work at all, and would likely need to be administered regularly. I’m fairly confident that the method could reduce severity of rejection, but that’s still only fairly lol. But, (disclaimer again), the method should work in either a single or small number of treatments for autoimmune diseases.

I hope like hell this gets into human trials fast. I have a personal stake in it (hence all the reading lol) and what this thing can’t do is undo the damage already done. The person being treated is still going to have whatever degree of disability the disease already caused, so the sooner people can start the treatment, the better off they are.

Most of the diseases explicitly listed as targets for this treatment are fucking brutal. Just one year with MS, as an example, can take someone from healthy and active to being half blind, or unable to walk unaided, or any number of other issues. MS already takes time to diagnose, so pretty much everyone that has it has some degree of disability by the time they start existing treatments. And the existing treatments, as incredible as they are, don’t fully prevent new damage occurring. Nor do all of them work at full efficacy for everyone. You can end up having to try multiple treatments to find the right one for your immune system.

So, most MS patients have a serious amount of time before their disease even gets slowed. My wife, from diagnosis to first partially effective treatment, went almost a year, and lost so damn much from that time plus the effects from before diagnosis. You’re talking someone that was modeling and a jogger being unable to walk down a hallway until over a year of physical therapy, and still can’t handle long walks.

And she didn’t even lose as much as some people do. She also deals with what’s called relapsing/remitting MS (RRMS) which takes breaks between attacks. People with primary progressive MS (PPMS) can lose function faster and more severely. It’s a fucking terrifying disease.

This is starting to go very long and tangential, so I’ll stop after this bit.

I hope like hell it will work for not only the listed diseases, but rejection too. Gods, the lives it could make better if it can do all of that would change the world, along with the individual lives. It would be the scientific equivalent of a miracle cure.

be_excellent_to_each_other ,
@be_excellent_to_each_other@kbin.social avatar

If we assume for a moment that it works as advertised - what is it that makes this a vaccine? To me it sounds like a cure or treatment.

NMBA ,
@NMBA@mstdn.ca avatar

@be_excellent_to_each_other @m3t00
Vaccines have evolved from prevention/mitigation to now include treatment, and ideally cures.

https://www.pennmedicine.org/mrna

be_excellent_to_each_other ,
@be_excellent_to_each_other@kbin.social avatar

So skimming through the link, it's a vaccine because it's still triggering a specific body response to fight the illness as opposed to directly attacking the illness itself? Is that a reasonable layman's summary of why it's called a vaccine?

(Old x'er here, Vaccines have been preventative for as long as I've ever known, that's the reason for the question.)

NMBA ,
@NMBA@mstdn.ca avatar

@be_excellent_to_each_other @m3t00
I an X that had the exact same thoughts lol. I’m no expert, but old vaccines often contained some of the virus live or deactivated, whereas mRNA are created and not of biological origin. So more about the front end than the back end.

SocialMediaRefugee ,

The article says the immune system has a mechanism for teaching it not to attack every time there is a damaged cell via a process in the liver. They are saying they can take a protein, say myelin, and attach it to a sugar called pGal, and it will get ported to the liver where it will also get “trained” to not attack myelin. Then the immune system shouldn’t attack nerve fibers as in MS.

So I guess it qualifies as a vaccine as it is involved in training the immune system though in this case to NOT attack something.

whoisearth ,
@whoisearth@lemmy.ca avatar

The amount of science research funded over COVID that allowed for the rapid development and testing of mRNA technology has created a boon for centuries to come. COVID may well be responsible for the death of autoimmune diseases.

Kethal ,

The creators call it an inverse vaccine. A vaccine causes the immune system to recognize a compound to attack. This treatment causes the immune system to ignore a compound it had previously recognized. So they are specifically saying it’s not a vaccine (and OP is misrepresenting them), even though that word is in the phrase, something roughly like antivenom is not a venom.

be_excellent_to_each_other ,
@be_excellent_to_each_other@kbin.social avatar

Thanks for the additional clarification!

winterayars ,

It is not a cure for the reasons others in this thread have stated. It doesn’t repair damage already done, it only prevents the disease from advancing. That’s still a huge deal, though.

GoodEye8 ,

But when it comes to type 1 diabetes the cause is the body destroying beta cells in the pancreas and everything else is a symptom of that. If you can make the body “forget” killing beta cells (like the article states the anti-vaccine would, or rather teach the body to not kill) then it would make sense for the body to recover and repair the damage done.

Wouldn’t it then be a cure?

tswerts ,

Yes, from what I know about type 1 diabetes is that once your immune system stops destroying your beta-cells, they regenerate. So that would solve your type 1 diabetes. And you’d have as big a chance of type 2 diabetes as the next guy. And isn’t that the dream 🙂 So 🤞

Chainweasel ,

Sounds pretty advanced. I bet they won’t be able to activate the mind control chips until 6G cell services launch.

krotti ,

I was under the impression that we were 5G access points with the covid vaccine?

Was I lied to? I thought I was doing a service to the fellow terminally online.

Downcount ,

In my understanding this could reverse the autoimmune reaction to Type 1 Diabetes not regrow the already killed β-cells.

JakenVeina ,

I was wondering about that, curing Type 1 Diabetes would be a HELL of a breakthrough.

Downcount ,

Curing it would lead to massive losses of a specific industry.

Bransons404 ,

It really would. I fear that anything remotely close to a “cure” would be thwarted by pharma because they profit so much from insulin.

I switched jobs a few months ago, and had about 2 weeks without insurance. my insulin prescription was over $4k.

I know that “pharma” can’t just shut something down… but I’m sure there’s some loophole

southsamurai ,
@southsamurai@sh.itjust.works avatar

That’s the way it reads, yes.

It would, if effective in human use, stop new damage, but not reverse existing damage.

Jumi ,

What about alopecia?

Nacktmull ,

What about Hashimoto’s thyroiditis and Graves’ disease?

toiletobserver ,

Only “ten more years to cure diabetes”

-Science 30 years ago

BloodSlut ,

This still wont cure diabetes, but it will prevent it from developing or advancing if you catch it early enough.

sigmaklimgrindset ,

Curing diabetes isn’t as profitable as selling insulin. That’s why it doesn’t get funded.

SCB ,

This doesn’t hold any water, logically.

If you’re selling insulin and I cure/prevent diabetes with a single treatment t, you no longer have a market and I have literally every human being on the planet.

Medical science is an arms race, and cures are nukes. You make the best cure, you win. Full stop.

sigmaklimgrindset ,

Medical science is an arms race, and cures are nukes. You make the best cure, you win. Full stop.

You would think that, except pharmaceutical research is rigged towards the few giant corporations that hold the patents. Sure, medical research is an arms race, but who is funding your research? If you find a cure but Pfizer funds you they can patent the cure and bury it or make it cost prohibitive in a variety of different ways.

The original insulin patent is open. Then why does it cost so much money to get insulin for Americans? Again, corporate patent trolling and controlling the funding for research labs. This is why corporate monopolies need to be regulated.

(Also I didn’t realize we do downvoting for disagreements on Lemmy now too)

SCB ,

I didn’t downvotes you for a disagreement, but because you’re spreading false conspiracy theories in a science community.

Also I get downvotes for saying true things people don’t like all the time. It isn’t a big deal.

sigmaklimgrindset ,

Sure, I’m spreading conspiracy theories. Not like I left chronic disease research and restarted in a completely unrelated field for this exact problem.

I didn’t work for Pfizer, but I did work for another pharmaceutical company you would recognize the name of if you live in North America. And let me tell you, while the labs are trying to do good, the executives and management are rotten to the core. Unless it’s a life threatening infectious disease, they will not prioritize the research. It’s not active suppression most of the time, it’s willful negligence and underfunding. I got into the field hopeful, and left jaded.

SCB ,

It’s not active suppression most of the time,

This is your initial claim, though.

sigmaklimgrindset ,

No, my initial claim was:

Curing diabetes isn’t as profitable as selling insulin. That’s why it doesn’t get funded.

Then you opined that whoever comes up with a cure wins, which should be true in a perfect world. In fact, most researchers would agree with you.

Unfortunately, a lot of MBA’s in these pharma companies don’t see it that way, and my reply to you was trying to outline the realities of that. I focussed more on the patent-and-bury part because this is the one method less known to the public (and less used), but underfunding research that can do a public good but isn’t profitable is a common technique by corporations in research, regardless of the discipline.

My bad, I thought this was common knowledge, but it probably isn’t for people who aren’t in PhD/post-doc research roles.

sigmaklimgrindset ,

Also, apologies if I come off as aggressive at any point, I still have a lot of residual anger over what I experienced with my former career.

southsamurai ,
@southsamurai@sh.itjust.works avatar

Dude. Never, ever whine about votes. It just draws down votes, and isn’t cool in the first place.

sigmaklimgrindset ,

I’m glad I wrote actually that actually, as the other commenter said they downvoted me for spreading conspiracy theories and I was able to clarify why I wasn’t.

SCB ,

This is the most boomer shit and it is so sad to see people still saying it

  • All
  • Subscribed
  • Moderated
  • Favorites
  • •
  • random
  • [email protected]
  • lifeLocal
  • goranko
  • All magazines
    •