So in theory an everdrive should (there was an issue with the pocket and some GB X7 due to a signal spike not present on the original Gameboy hardware). The main issue is that it’s a pretty large additional expense if you want a seamless experience (the x5 requires pressing the reset button to save). Say when this comes out it’s $350 with tax and shipping, which is pretty generous I think. You now have to spend an additional $200 for the cart to play roms. Now the choices in this price range are:
Analogue: $550
Mister: $615 (price of a fully configured kit with aluminum shell, can be priced cheaper if full diy)
Mars: $699
N64 + HDMI Mod: $620ish (eBay price $120 for a good condition console with expansion and controller, $200 for the mod, another $100 to install it if not diy).
I see this appealing to N64 enthusiasts that don’t already have a HDMI mod (current mods aren’t cheap and require soldering to install) or people that really want to play their old carts for that nostalgia hit.