Couldn’t tell you what the problem is, but I once had an issue with BioShock. The rerelease to be precise. The game would boot up just fine and I could access the bonus museum thing just fine, but as soon as I tried starting the actual game, the screen would go black and the sound of after the loading screen.
Couldn’t figure out what happened and just ended up deleting/uninstalling it because I didn’t have the time to fix it/diagnose the problem.