The largest hurdles to nuclear power are PR. Water usage of nuclear plants is able to recycle most if not all of what they utilize and the high energy density and capable power output makes it much more economical to pump water from further away to sustain the plant and needs of regional communities, especially compared to fossil fuels plants that largely use water in the same capacity as nuclear. If a coal or gas plant was viable in a location, then nuclear would be just as if not more capable in that location.
You could replace every coal plant in the world with nuclear and the only major logistics disruption would be supplying them with enough uranium.