If you want the applications to work on the memory interaction level, they have to be children of the same process. If you start a game launcher in wine, and then start a game from it, it can “see” that game process, close it, join friends, whatever.
But if you start the game exe directly, then separately start the launcher while the game is already running, then it won’t be able to see that there’s already a running game process.
It’s not always enough for the processes to just be part of the same file system (same prefix). If all you need is some input interactions like with voiceattack or trackIR, that doesn’t matter. But for memory hacks it does.
Wine has an internal task manager and if you just start processes without making sure they are running together, they’ll all end up in their own separate wine instances, even though they are on same prefix.