The only real downside with GE is that you’re basically reliant on one guy (GE == GloriousEggroll), but it’s all opensource, and more projects are collaborating with him now (like the guys behind Lutris and Heroic), so hopefully if the project stops for whatever reason, someone else can pick it up and continue.
And you can still have use regular Wine in case there’s any compatibility issues (eg using the version in Flatpak, or Bottles, or the extracted .tar.gz).