I wonder how well it integrates with hardware. Arch with the pacman packages has been the only distro where I could get ROCm working reliably. I'd love to make a "ROCm container" and dump all that mess into it's own sandbox.
In fact, the thing I really want is more of a "Qubes but not for security tryhards" (aka I can actually use Wayland AND game on it) where everything gets it's own container mainly for organizational purposes, but something like this sounds like a fair compromise.