Probably somebody can provide a better answer, but for me tmux is useful due that it has session manager (really useful if your remote connection drops) and the ability to split the screen in multiple screens (usually I split vertical, but you can create easily 4x4 screen).
The only trick is the learning curve of the actions (usually ctrl + b and the key required). For example to split the window vertical, you must do ctrl + b and then %.
But as I said, probably you will get better and more technical answers ^_^U