It’s a different work flow installing software. Flatpak first mentality, then install stuff in a Toolbox container, if that doesn’t work layer the rpm.
Being able to rebase has been helpful, I’ve based forward to rawhide a few times to try new packages and then rebase back to stable.
You lose things like being able to use packages out of copr, but used to only really use that to test new versions of KDE. However the devs created a branch for KDE testing anyway, so nothing lost.
Happy to answer any specific questions you might have