Yes, but first go check which list you want to use since they’re a good starting point to understand a kind of level of tolerance and expectations around your experience.
Be prepared for a bump in time outs as you work through things you might need (I blocked by accident a bunch of needed Microsoft services that I need to use during my job).
I haven’t edited my white list in months, maybe over a year. It’s going very well. I’ve been running pihole on ubuntu for more than 5 years as two virtual machines. I’m happy.